2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationCytotoxic T-lymphocyte-associated protein 4Rabbit liver tumor modelConventional TACEImmune checkpoint marker expressionLiver tumor modelVX2 rabbit liver tumor modelArterial chemoembolizationBicarbonate infusionImmune responseDifferentiation 3T-lymphocyte-associated protein 4Conventional transcatheter arterial chemoembolizationTumor modelCell death protein 1Marker expressionIntratumoral T cellsImmune checkpoint markersT cell infiltrationDeath protein 1Antigen-presenting cellsImmune cell recruitmentNew Zealand white rabbitsZealand white rabbitsAPC infiltration
2021
PET Image Denoising Using a Deep-Learning Method for Extremely Obese Patients
Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen M, Saperstein L, Pucar D, Kulon M, Liu C. PET Image Denoising Using a Deep-Learning Method for Extremely Obese Patients. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 766-770. PMID: 37284026, PMCID: PMC10241407, DOI: 10.1109/trpms.2021.3131999.Peer-Reviewed Original Research
2020
Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.
Young CR, Kulon ME, Boustani AM, Pucar D. Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy. Clinical Nuclear Medicine 2020, 46: e179-e180. PMID: 33086270, DOI: 10.1097/rlu.0000000000003340.Peer-Reviewed Original ResearchConceptsPET/CTAltered biodistributionMediastinal T-cell lymphoblastic lymphomaPosttreatment FDG PET/CTFDG PET/CTT-cell lymphoblastic lymphomaSubcutaneous white adipose tissueWhite adipose tissueTreatment response assessmentSubcutaneous white fatAsparaginase chemotherapyLymphoblastic lymphomaAsparaginase resistanceFDG biodistributionResponse assessmentWhite fatGlucose metabolismAdipose tissueTreatment cyclesLeukemic cellsVisceral activityCTBiodistributionChemotherapyDiffuse activityDiagnostic approach to primary retroperitoneal pathologies: what the radiologist needs to know
Czeyda-Pommersheim F, Menias C, Boustani A, Revzin M. Diagnostic approach to primary retroperitoneal pathologies: what the radiologist needs to know. Abdominal Radiology 2020, 46: 1062-1081. PMID: 32944824, DOI: 10.1007/s00261-020-02752-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMolecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancementMolecular Imaging of the Immuno-metabolic Cross-Talk reveals Resistance Mechanisms in a Rabbit Liver Cancer Model.
RadiologyPeer-Reviewed Original ResearchOpening Up the Ovary: A Multimodality Approach to Imaging Ovarian Neoplasms with Pathology Correlation.
RadiographicsBooksDiagnostic Approach to Primary Retroperitoneal Pathologies: What the Radiologist Needs to Know.
Abdominal RadiologyBooks
2018
Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis
Pucar D, Boustani AM, Bronen RA, Saperstein L. Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis. Clinical Nuclear Medicine 2018, 43: 284-286. PMID: 29401149, DOI: 10.1097/rlu.0000000000001981.Peer-Reviewed Educational MaterialsConceptsSinus diseasePituitary swellingSevere headacheVisual disturbancesLaboratory findingsMetastatic melanomaPituitary abnormalitiesRetrospective analysisContrast CTNoncontrast CTPituitary hormonesHypophysitisHeadacheDiseaseDiagnosisCTLow levelsNivolumabHypermetabolismImmunotherapyPETMelanomaAbnormalitiesFindingsHormoneMolecular imaging of prostate cancer
Boustani AM, Pucar D, Saperstein L. Molecular imaging of prostate cancer. British Journal Of Radiology 2018, 91: 20170736. PMID: 29243485, PMCID: PMC5966010, DOI: 10.1259/bjr.20170736.Peer-Reviewed Original ResearchConceptsProstate cancerNational Comprehensive Cancer Network guidelinesMetastatic diseaseMolecular imagingCommon malignancyNetwork guidelinesEffective treatmentMolecular imaging techniquesCancerMetabolic intermediaryTreatmentImaging techniquesRelevant radiotracersImagingTimely detectionAccurate imagingChemotherapySurgeryRecurrenceMalignancyDiseaseReceptors