2019
Hypervascularization in mTOR‐dependent focal and global cortical malformations displays differential rapamycin sensitivity
Zhang L, Huang T, Teaw S, Bordey A. Hypervascularization in mTOR‐dependent focal and global cortical malformations displays differential rapamycin sensitivity. Epilepsia 2019, 60: 1255-1265. PMID: 31125447, PMCID: PMC6558978, DOI: 10.1111/epi.15969.Peer-Reviewed Original ResearchConceptsBlood vesselsRapamycin treatmentVessel densityVessel abnormalitiesPostnatal day 14 miceAbsence of seizuresWild-type miceConditional transgenic miceTuberous sclerosis complexTypes of MCDDay 14 miceMCD modelFocal MCDMTOR blockersDysplastic neuronsFunctional outcomeEpilepsy treatmentSomatosensory cortexYoung miceFocal malformationsCortical developmentJuvenile miceTotal vessel lengthAnimal modelsTransgenic mice
2016
Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neuroscience Letters 2016, 614: 112-118. PMID: 26812181, DOI: 10.1016/j.neulet.2015.12.042.Peer-Reviewed Original ResearchConceptsNeural stem cellsSubventricular zoneNeonatal subventricular zoneWeek old miceTuberous sclerosis complexStem cellsNewborn neuroblastsYoung miceOld miceProgressive lossYoung adultsRapamycin complex 1Mechanistic targetRecent evidenceProliferative cellsMiceHyperactive mTORC1Terminal differentiationCellsMTORC1 activationProliferationActivationMTORC1NeurogenesisHyperactivity
2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic response