2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic response
2010
Prostaglandin E2 induces glutamate release from subventricular zone astrocytes.
Dave KA, Platel JC, Huang F, Tian D, Stamboulian-Platel S, Bordey A. Prostaglandin E2 induces glutamate release from subventricular zone astrocytes. Neuron Glia Biology 2010, 6: 201-7. PMID: 21211110, DOI: 10.1017/s1740925x10000244.Peer-Reviewed Original ResearchConceptsAmbient glutamate levelsProstaglandin E2Subventricular zoneGlutamate releaseAstrocyte-like cellsGlutamate levelsGramicidin-perforated patch-clamp techniquesIntracellular Ca2Application of PGE2Aspartate receptor channelsPatch-clamp techniqueLateral ventricleSVZ cellsPGE2 releaseChoroid plexusMature astrocytesNeuroblast survivalEnzyme immunoassayReceptor channelsAstrocytesE2Ca2CellsReleaseLesser extentNMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network
Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network. Neuron 2010, 65: 859-872. PMID: 20346761, PMCID: PMC2861893, DOI: 10.1016/j.neuron.2010.03.009.Peer-Reviewed Original ResearchConceptsAdult-born neuronsNMDA receptorsNMDAR activitySynaptic networksNeuroblast survivalGlutamate release machineryAstrocyte-like cellsLoss of neuroblastsNeonatal electroporationSpecialized astrocytesAstrocytic glutamateOlfactory bulbVesicular releaseRelease machineryReceptorsNeuroblastsNeuronsIntercellular mechanismsSurvivalGlutamateNeuroblast apoptosisAstrocytesNeurogenesisNeurotransmittersSVZNeurotransmitter signaling in postnatal neurogenesis: The first leg
Platel JC, Stamboulian S, Nguyen I, Bordey A. Neurotransmitter signaling in postnatal neurogenesis: The first leg. Brain Research Reviews 2010, 63: 60-71. PMID: 20188124, PMCID: PMC2862802, DOI: 10.1016/j.brainresrev.2010.02.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFate determinationSonic hedgehogNeurotransmitter signalingDifferent cell typesSubventricular zoneMultitude of receptorsMaster regulatorGenetic signaturesMosaic natureGamma-aminobutyric acidMicroenvironmental signalsCell typesIntracellular pathwaysAstrocyte-like cellsFunction of neurotransmittersHedgehogSignalingNeurogenesisNeurogenic zonesAdult brainPostnatal neurogenesisPeripheral organsNeurotransmitter functionSynaptic integrationGenesGABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels
Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A. GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels. Frontiers In Cellular Neuroscience 2010, 4: 8. PMID: 20422045, PMCID: PMC2857959, DOI: 10.3389/fncel.2010.00008.Peer-Reviewed Original ResearchVoltage-gated calcium channelsT-type voltage-gated calcium channelsAstrocyte-like cellsSubventricular zoneReceptor activationCalcium channelsFunctional voltage-gated calcium channelsChannel activator BayK 8644Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterNeurogenic subventricular zonePostnatal subventricular zoneAcidic protein promoterAmbient GABABayK 8644Transgenic miceReceptor activityL-typeProtein promoterReceptorsTonicActivationCellsIntracellularMibefradilImaging and Recording Subventricular Zone Progenitor Cells in Live Tissue of Postnatal Mice
Lacar B, Young SZ, Platel JC, Bordey A. Imaging and Recording Subventricular Zone Progenitor Cells in Live Tissue of Postnatal Mice. Frontiers In Neuroscience 2010, 4: 43. PMID: 20700392, PMCID: PMC2918349, DOI: 10.3389/fnins.2010.00043.Peer-Reviewed Original ResearchSubventricular zoneSVZ cellsSubventricular zone progenitor cellsPatch-clamp recordingsCell populationsAstrocyte-like cellsFluorescent reporter miceRNA interference technologyNeurogenic zonesAcute slicesCellular diversityGlial cellsLateral ventricleMultiple cell populationsOlfactory bulbPostnatal brainClamp recordingsReporter miceFloxed miceTransgenic micePostnatal miceCalcium activityMiceProgenitor cellsGenetic labeling
2004
GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone
Bolteus AJ, Bordey A. GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone. Journal Of Neuroscience 2004, 24: 7623-7631. PMID: 15342728, PMCID: PMC6729616, DOI: 10.1523/jneurosci.1999-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBicucullineBiological TransportBrainCalcium SignalingCell MovementGABA Plasma Membrane Transport ProteinsGABA-A Receptor AgonistsGamma-Aminobutyric AcidMass SpectrometryMembrane Transport ProteinsMiceMicroscopy, VideoNeuronsPatch-Clamp TechniquesPotassiumReceptors, GABA-AStem CellsConceptsAstrocyte-like cellsSubventricular zoneNeuronal precursorsPostnatal subventricular zoneNeuronal precursor migrationCell migrationPrecursor migrationPresence of bicucullineEnhancement of GABAAnterior subventricular zoneInhibition of GABARostral migratory streamAmbient GABA levelsApplication of GABASagittal brain slicesAntagonist bicucullineGABA releaseEndogenous GABAGABA levelsBrain slicesAdult miceGABA transporterMigratory streamGABACell depolarization
1998
Expression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors