2012
Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia
Tan A, Chakrabarty S, Kimura H, Martin J. Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia. Journal Of Neuroscience 2012, 32: 12896-12908. PMID: 22973013, PMCID: PMC3499628, DOI: 10.1523/jneurosci.6451-11.2012.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsMaleNerve RegenerationNeuronal PlasticityPyramidal TractsRatsRats, Sprague-DawleyReflex, AbnormalConceptsCorticospinal tract injurySpinal cordCorticospinal tractProprioceptive afferentsAfferent fiber sproutingGray matter regionsFrequency-dependent depressionCorticospinal tract terminalsCervical spinal cordMechanisms of maladaptive plasticityMatter regionsSpinal cord projectionsSpinal cord injuryPyramidal tract sectionTract injurySpared sideAdult ratsFiber sproutingAfferent terminalsSpinal targetsMicroglial densityMuscle afferentsSpinal sensorimotor circuitsMaladaptive plasticityAfferents
2007
Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state
Tan A, Petruska J, Mendell L, Levine J. Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. Experimental Neurology 2007, 206: 257-268. PMID: 17585905, PMCID: PMC3103885, DOI: 10.1016/j.expneurol.2007.05.013.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal columnsChronic pathophysiological stateNerve conditioning lesionConditioning lesionRegenerating axonsCord injurySensory afferentsInjury siteFrequency-following abilityInfusion of antibodiesPathophysiological statesIntrinsic growth stateExperimental spinal cord injuryRegenerating sensory axonsReduced conduction velocityIntrinsic growth capacitySensory axon growthAxonal growthGrowth inhibitory effectSensory neuronsSpinal cordCombinatorial treatmentInhibit axonal growthRepetitive stimuli