2009
Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing
Tan AM, Choi JS, Waxman SG, Hains BC. Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing. Journal Of Neurophysiology 2009, 102: 2396-2409. PMID: 19692517, DOI: 10.1152/jn.00095.2009.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injurySynaptic transmissionDorsal horn nociceptive neuronsFrequency-following abilityDendritic spine remodelingGeneration of painAction potential activationDendritic spine morphologyDendritic spine shapeAbnormal painCentral sensitizationNociceptive neuronsSpine remodelingPostsynaptic neuronsDendritic spinesSpine morphologyInput-output functionPainSoma resultsInjurySpine shapeNeuronal statesNeuronsPotential activation
2007
Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state
Tan A, Petruska J, Mendell L, Levine J. Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. Experimental Neurology 2007, 206: 257-268. PMID: 17585905, PMCID: PMC3103885, DOI: 10.1016/j.expneurol.2007.05.013.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal columnsChronic pathophysiological stateNerve conditioning lesionConditioning lesionRegenerating axonsCord injurySensory afferentsInjury siteFrequency-following abilityInfusion of antibodiesPathophysiological statesIntrinsic growth stateExperimental spinal cord injuryRegenerating sensory axonsReduced conduction velocityIntrinsic growth capacitySensory axon growthAxonal growthGrowth inhibitory effectSensory neuronsSpinal cordCombinatorial treatmentInhibit axonal growthRepetitive stimuli