2024
Li-Fraumeni Syndrome: Imaging Features and Guidelines.
Gosangi B, Dixe de Oliveira Santo I, Keraliya A, Wang Y, Irugu D, Thomas R, Khandelwal A, Rubinowitz A, Bader A. Li-Fraumeni Syndrome: Imaging Features and Guidelines. RadioGraphics 2024, 44: e230202. PMID: 39024172, DOI: 10.1148/rg.230202.Peer-Reviewed Original ResearchConceptsLi-Fraumeni syndromeLifetime risk of cancerRare autosomal dominant familial cancer syndromeIncreased riskRisk of cancerTreated with total mastectomyAutosomal dominant familial cancer syndromeImaging features of tumorsFamilial cancer syndromeWhole-body MRIAnnual screeningFeatures of tumorsCancer syndromesLifetime riskP53 transcription factorLi-FraumeniAdrenocortical cancerTotal mastectomyPrimary cancerBreast malignancyImaging guidelinesBreast cancerGermline mutationsColon cancerManagement guidelinesDisorders with Ophthalmic and Thoracic Involvement.
Gosangi B, Lang P, Johnson M, Zukerman R, Tu L, Traube L, Bader A, Rubinowitz A. Disorders with Ophthalmic and Thoracic Involvement. RadioGraphics 2024, 44: e230132. PMID: 38870047, DOI: 10.1148/rg.230132.Peer-Reviewed Original ResearchConceptsClinical manifestationsExamination of family membersEhlers-Danlos syndromeAffecting patient outcomesAcute sarcoidosisOphthalmologic examinationThoracic symptomsDry eyeThoracic involvementOphthalmological symptomsOphthalmologic manifestationsEye symptomsMarfan syndromeSjogren's syndromeImaging findingsRadiological studiesLung diseasePatient outcomesEhlers-DanlosFamily membersMultimodal imagingSystem conditionsSyndromeThoracicSarcoidosis
2020
Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib
Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLymphoma, T-CellMaleMiddle AgedNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesSARS-CoV-2Severity of Illness IndexTransplantation, HomologousTreatment OutcomeConceptsAllogeneic hematopoietic stem cell transplant patientsHematopoietic stem cell transplant patientsSevere acute respiratory syndrome coronavirus 2SARS coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 pneumoniaAcute respiratory syndrome coronavirus 2Stem cell transplant patientsSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Coronavirus 2 infectionCell transplant patientsCoV-2 infectionStem cell transplantationSyndrome coronavirus 2High death rateImmunocompromised stateJAK/STAT inhibitor ruxolitinibTransplant patientsCell transplantationCoronavirus 2Novel therapiesInhibitor ruxolitinibPatientsDeath rateRuxolitinibImaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain
Bader AS, Rubinowitz AN, Gange CP, Bader EM, Cortopassi IO. Imaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain. The American Journal Of Medicine 2020, 133: 1135-1142. PMID: 32442508, DOI: 10.1016/j.amjmed.2020.04.013.Peer-Reviewed Educational MaterialsMeSH KeywordsChest PainEsophageal Motility DisordersFractures, CompressionGastroesophageal RefluxHernia, HiatalHumansMagnetic Resonance ImagingMusculoskeletal DiseasesPleural EffusionPneumoniaPneumothoraxPrimary Health CareRadiography, ThoracicRespiratory Tract DiseasesRib FracturesSpinal FracturesThoracic WallTietze's SyndromeTomography, X-Ray ComputedConceptsChest painPrimary care settingCare settingsNoncardiac chest painCommon presenting complaintPrimary care physiciansMultiple organ systemsNoncardiac sourcesPresenting complaintCare physiciansMusculoskeletal etiologyRadiologic appearancePainNumerous imaging modalitiesOrgan systemsImaging modalitiesAppropriate testsEtiologyCliniciansFindingsPhysiciansSettingComplaintsImaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 1: Cardiovascular Etiologies
Bader AS, Rubinowitz AN, Gange CP, Bader EM, Cortopassi IO. Imaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 1: Cardiovascular Etiologies. The American Journal Of Medicine 2020, 133: 1033-1038. PMID: 32442507, DOI: 10.1016/j.amjmed.2020.04.024.Peer-Reviewed Educational MaterialsConceptsChest painPrimary care settingCardiovascular etiologyCare settingsCommon presenting complaintPrimary care physiciansMultiple organ systemsPresenting complaintCare physiciansPainNumerous imaging modalitiesOrgan systemsImaging modalitiesEtiologyAppropriate testsCliniciansFindingsPhysiciansSettingComplaints
2019
Distribution of Mediastinal Lesions Across Multi-Institutional, International, Radiology Databases
Roden AC, Fang W, Shen Y, Carter BW, White DB, Jenkins SM, Spears GM, Molina JR, Klang E, Segni M, Ackman JB, Sanchez EZ, Girard N, Shumeri E, Revel MP, Chassagnon G, Rubinowitz A, Dicks D, Detterbeck F, Ko JP, Falkson C, Sigurdson S, Segreto S, Del Vecchio S, Palmieri G, Ottaviano M, Marino M, Korst R, Marom EM. Distribution of Mediastinal Lesions Across Multi-Institutional, International, Radiology Databases. Journal Of Thoracic Oncology 2019, 15: 568-579. PMID: 31870881, DOI: 10.1016/j.jtho.2019.12.108.Peer-Reviewed Original ResearchConceptsMediastinal lesionsDistribution of lesionsBenign cystsMediastinal compartmentPositron emission tomography-computed tomographyEmission tomography-computed tomographyCommon mediastinal lesionsMulti-institutional cohortTomography-computed tomographyBenign mediastinal cystsParavertebral lesionsThymic carcinomaThymic hyperplasiaMediastinal massNeurogenic tumorsSurgical databaseMediastinal cystsRadiology databaseSingle institutionCommon lesionsMediastinal abnormalitiesDifferential diagnosisMediastinal noduleComputed tomographyDemographic data
2015
The Wonderful World of the Windpipe: A Review of Central Airway Anatomy and Pathology
Lawrence DA, Branson B, Oliva I, Rubinowitz A. The Wonderful World of the Windpipe: A Review of Central Airway Anatomy and Pathology. Canadian Association Of Radiologists Journal 2015, 66: 30-43. PMID: 25623009, DOI: 10.1016/j.carj.2014.08.003.Peer-Reviewed Original ResearchA Tour of the Thymus: A Review of Thymic Lesions With Radiologic and Pathologic Correlation
Goldstein AJ, Oliva I, Honarpisheh H, Rubinowitz A. A Tour of the Thymus: A Review of Thymic Lesions With Radiologic and Pathologic Correlation. Canadian Association Of Radiologists Journal 2015, 66: 5-15. PMID: 24736228, DOI: 10.1016/j.carj.2013.09.003.Peer-Reviewed Original ResearchConceptsThymic lesionsCross-sectional imaging studiesAssociated medical conditionsDifferent pathologic lesionsAccurate radiographic diagnosisThymic hyperplasiaPathologic featuresPathologic correlationPathologic lesionsMedical conditionsUnnecessary followRadiographic diagnosisImaging studiesLesionsDifferent lesionsVariable appearanceThymusPeriods of stressRadiologicHyperplasiaFollowChestDiagnosis
2012
Etiologies of bilateral pleural effusions
Puchalski JT, Argento AC, Murphy TE, Araujo KL, Oliva IB, Rubinowitz AN, Pisani MA. Etiologies of bilateral pleural effusions. Respiratory Medicine 2012, 107: 284-291. PMID: 23219348, PMCID: PMC5421548, DOI: 10.1016/j.rmed.2012.10.004.Peer-Reviewed Original ResearchConceptsRate of pneumothoraxBilateral thoracentesisExudative effusionsMalignant effusionsMultiple etiologiesCombination of etiologiesCommon single etiologyBilateral pleural effusionOutcomes of patientsOverall complication rateChest tube drainageProspective cohort studyCongestive heart failurePleural fluid characteristicsPleural fluid formationAcademic medical centerBilateral effusionsMore etiologiesMost effusionsCohort studyComplication rateTube drainageBilateral proceduresConsecutive patientsHeart failureInterstitial lung disease
Murray LA, Rubinowitz A, Herzog EL. Interstitial lung disease. Current Opinion In Rheumatology 2012, 24: 656-662. PMID: 22955020, DOI: 10.1097/bor.0b013e3283588de4.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisInterstitial lung diseaseSSc-ILDClinical presentationPulmonary fibrosisLung diseaseRecent clinical trialsConcepts of pathogenesisLymphocyte subsetsOrigin of fibroblastsEpithelial injuryLung fibrosisPathologic criteriaPredictive biomarkersPathogenic roleClinical trialsDisease progressionCell injuryPutative biomarkersDiseaseFibrosisDeadly diseaseCommon formMillions of peopleDevastating diseaseInterstitial Lung Disease in the Connective Tissue Diseases
Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA. Interstitial Lung Disease in the Connective Tissue Diseases. Clinics In Chest Medicine 2012, 33: 123-149. PMID: 22365251, DOI: 10.1016/j.ccm.2012.01.004.Peer-Reviewed Original ResearchConceptsConnective tissue diseaseInterstitial lung diseaseLung diseaseTissue diseaseIdiopathic interstitial lung diseaseFulminant respiratory failureCTD-ILDRespiratory failureImmunosuppressive agentsHealthy patientsDrug reactionsFirst manifestationGradual onsetDiseaseCareful searchSubtle evidenceDyspneaCorticosteroidsCoughPatientsInfectionDiagnosis
2011
Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective
Oliva IB, Cortopassi F, Rochester CL, Rubinowitz AN. Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective. Monaldi Archives For Chest Disease 2011, 75: 220-34. PMID: 22462310, DOI: 10.4081/monaldi.2011.210.Peer-Reviewed Original ResearchConceptsCombined pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisLung zonesChronic Obstructive Pulmonary Disease - ResultsProgressive parenchymal lung diseaseParenchymal lung diseaseUpper lung zonesLower lung zonesFindings of emphysemaUnderdiagnosed syndromeRadiological findingsSignificant morbidityWorse prognosisEmphysema syndromeLung diseaseEarly recognitionRadiologic appearanceRadiologic perspectiveComputed tomographyClinical importanceDisease resultsFibrosisSyndromeRapid treatment
2010
A 71-Year-Old Woman With Myelofibrosis, Hypoxemia, and Pulmonary Hypertension
Trow TK, Argento AC, Rubinowitz AN, Decker R. A 71-Year-Old Woman With Myelofibrosis, Hypoxemia, and Pulmonary Hypertension. CHEST Journal 2010, 138: 1506-1510. PMID: 21138888, DOI: 10.1378/chest.10-0973.Peer-Reviewed Original ResearchAgedAntimonyBiopsy, NeedleBlood Chemical AnalysisCardiac CatheterizationDiagnosis, DifferentialDyspneaFemaleHematopoiesis, ExtramedullaryHumansHypertension, PulmonaryHypoxiaImmunohistochemistryLung DiseasesPhysical ExaminationPrimary MyelofibrosisRadionuclide ImagingRare DiseasesRespiratory Function TestsTechnetium CompoundsTomography, X-Ray ComputedPulmonary Manifestations of Rheumatoid Arthritis
Antin-Ozerkis D, Evans J, Rubinowitz A, Homer RJ, Matthay RA. Pulmonary Manifestations of Rheumatoid Arthritis. Clinics In Chest Medicine 2010, 31: 451-478. PMID: 20692539, DOI: 10.1016/j.ccm.2010.04.003.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisPulmonary diseaseLung diseaseInterstitial lung diseaseUse of drugsPulmonary manifestationsAirway diseaseRheumatoid nodulesPleural effusionRespiratory abnormalitiesPulmonary toxicityArthritisDiseaseDiagnostic assessmentMultidisciplinary approachMorbidityEffusionInfectionMortalityAbnormalitiesCirculating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype
Mathai SK, Gulati M, Peng X, Russell TR, Shaw AC, Rubinowitz AN, Murray LA, Siner JM, Antin-Ozerkis DE, Montgomery RR, Reilkoff RA, Bucala RJ, Herzog EL. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Laboratory Investigation 2010, 90: 812-823. PMID: 20404807, PMCID: PMC3682419, DOI: 10.1038/labinvest.2010.73.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseSSc-ILD patientsSSc-ILDIL-10Normal controlsProfibrotic cellsSystemic sclerosisLung diseaseCollagen-producing cellsMCP-1Profibrotic phenotypeSSc-related interstitial lung diseaseFlow cytometryPeripheral blood profilesSSc-ILD cohortsIL-10 secretionSystemic sclerosis patientsExpression of CD163Blood of patientsHealthy aged controlsCultured CD14Profibrotic characteristicsProfibrotic mediatorsTNF levelsSclerosis patientsClassification of the Thoroughness of Mediastinal Staging of Lung Cancer
Detterbeck F, Puchalski J, Rubinowitz A, Cheng D. Classification of the Thoroughness of Mediastinal Staging of Lung Cancer. CHEST Journal 2010, 137: 436-442. PMID: 20133290, DOI: 10.1378/chest.09-1378.BooksSpontaneous Hemothorax and Recurrent Hemoptysis in a 26-Year-Old Man With Skin Lesions
Selim B, Lane CR, Rubinowitz AN, Siner JM. Spontaneous Hemothorax and Recurrent Hemoptysis in a 26-Year-Old Man With Skin Lesions. CHEST Journal 2010, 137: 480-483. PMID: 20133296, DOI: 10.1378/chest.09-1030.Peer-Reviewed Case Reports and Technical NotesExtramedullary Hematopoiesis Associated with β-Thalassemia
Smitaman E, Rubinowitz AN. Extramedullary Hematopoiesis Associated with β-Thalassemia. New England Journal Of Medicine 2010, 362: 253. PMID: 20089975, DOI: 10.1056/nejmicm0810132.Peer-Reviewed Original Research
2009
Routine daily vs on-demand chest radiographs in intensive care
Siegel MD, Rubinowitz AN. Routine daily vs on-demand chest radiographs in intensive care. The Lancet 2009, 374: 1656-1658. PMID: 19896185, DOI: 10.1016/s0140-6736(09)61632-9.Peer-Reviewed Original ResearchOf Lungs, Lipids, and Lollipops
Mathai SK, Rubinowitz AN, Homer RJ, Detterbeck F, Herzog EL. Of Lungs, Lipids, and Lollipops. CHEST Journal 2009, 136: 1420-1423. PMID: 19892683, DOI: 10.1378/chest.08-2133.Peer-Reviewed Case Reports and Technical Notes