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Featured Publications
SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection
Greaney A, Raredon M, Kochugaeva M, Niklason L, Levchenko A. SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection. IScience 2023, 26: 106175. PMID: 36788793, PMCID: PMC9912025, DOI: 10.1016/j.isci.2023.106175.Peer-Reviewed Original ResearchDecellularization compromises mechanical and structural properties of the native trachea
Greaney A, Ramachandra A, Yuan Y, Korneva A, Humphrey J, Niklason L. Decellularization compromises mechanical and structural properties of the native trachea. Biomaterials And Biosystems 2023, 9: 100074. PMID: 36967724, PMCID: PMC10036236, DOI: 10.1016/j.bbiosy.2023.100074.Peer-Reviewed Original ResearchThe History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future
Greaney A, Niklason L. The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future. Tissue Engineering Part B Reviews 2021, 27: 341-352. PMID: 33045942, PMCID: PMC8390779, DOI: 10.1089/ten.teb.2020.0238.Peer-Reviewed Original ResearchPlatform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing
Greaney AM, Adams TS, Raredon M, Gubbins E, Schupp JC, Engler AJ, Ghaedi M, Yuan Y, Kaminski N, Niklason LE. Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing. Cell Reports 2020, 30: 4250-4265.e6. PMID: 32209482, PMCID: PMC7175071, DOI: 10.1016/j.celrep.2020.03.004.Peer-Reviewed Original Research
2026
20 years of Progress in Stem Cells, Cell Therapy, and Bioengineering in Lung Biology and Diseases
Greaney A, Orr J, Moore S, Ikonomou L, Weiss D, Ryan A. 20 years of Progress in Stem Cells, Cell Therapy, and Bioengineering in Lung Biology and Diseases. American Journal Of Respiratory Cell And Molecular Biology 2026, aanag126. PMID: 42286350, DOI: 10.1093/ajrcmb/aanag126.Peer-Reviewed Original ResearchThis study reviews 20 years of advances in stem cells, bioengineering, and cell therapy for lung regeneration and disease treatment.Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign
Girard R, Tran J, Cai Y, Farach-Carson M, Nia H, Greaney A, Niklason L, Hurley K, Blanco E, Koc-Günel S, Karmouty-Quintana H. Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2026, 330: l653-l660. PMID: 42030197, PMCID: PMC13198914, DOI: 10.1152/ajplung.00066.2026.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEpithelial Reprogramming and Transition during Pulmonary Bioengineering.
Mizoguchi S, Lee V, Kim H, Edelstein SE, Wang N, Gracia MT, Danelski C, Haynes C, Rivero R, Stitelman D, Obata T, Greaney AM, Tsuchiya T, Kyriakides TR, Kaminski N, Raredon MSB. Epithelial Reprogramming and Transition during Pulmonary Bioengineering. BioRxiv 2026 PMID: 41659587, DOI: 10.64898/2026.01.24.701406.Peer-Reviewed Original Research
2023
Rational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.Peer-Reviewed Original Research
2022
Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome
Raredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome. Scientific Reports 2022, 12: 4187. PMID: 35264704, PMCID: PMC8906120, DOI: 10.1038/s41598-022-07959-x.Peer-Reviewed Original ResearchExpression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nature Communications 2022, 13: 430. PMID: 35058453, PMCID: PMC8776770, DOI: 10.1038/s41467-022-28043-y.Peer-Reviewed Original Research
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