2014
Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism
Dager AD, McKay DR, Kent JW, Curran JE, Knowles E, Sprooten E, Göring H, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism. Neuropsychopharmacology 2014, 40: 412-420. PMID: 25079289, PMCID: PMC4443955, DOI: 10.1038/npp.2014.187.Peer-Reviewed Original ResearchConceptsAmygdala volumeSubcortical volumesFamily historyLifetime AUDAlcohol-related damageGenetic factorsSmaller amygdala volumesPre-existing deficitsAUD riskSuch family historyStructural brain imagesBrain shrinkageDorsal striatumAlcohol abuseNeurotoxic damageVentral striatumSubcortical structuresCommon genetic factorsShared genetic factorsCommon genetic featuresUnrelated controlsMexican-American individualsGenetic featuresStriatumRisk
2012
Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers
Dager AD, Anderson BM, Stevens MC, Pulido C, Rosen R, Jiantonio‐Kelly R, Sisante J, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Pearlson GD. Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers. Alcohol Clinical And Experimental Research 2012, 37: e161-e171. PMID: 23078363, PMCID: PMC3548054, DOI: 10.1111/j.1530-0277.2012.01879.x.Peer-Reviewed Original ResearchConceptsAlcohol cue reactivityFamily historyHeavy drinkersCue reactivityLight drinkersHeavy drinkingMagnetic resonance imaging responseBOLD responseBlood oxygen level-dependent (BOLD) contrastAlcohol cuesVisual association regionsAlcohol use disorderAlcohol imagesFunctional magnetic resonance imaging (fMRI) responsesMedial frontal cortexGreater BOLD responseLevel-dependent contrastTemporo-parietal regionsRisk factorsFrontal cortexDorsal striatumUse disordersAnterior cingulateBeverage imagesImaging response