Featured Publications
Immediate and long‐term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross‐sectional international survey
Punia V, Daruvala S, Dhakar M, Zafar S, Rubinos C, Ayub N, Hirsch L, Sivaraju A, investigators F. Immediate and long‐term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross‐sectional international survey. Epilepsia 2024, 65: 909-919. PMID: 38358383, DOI: 10.1111/epi.17915.Peer-Reviewed Original ResearchAnti-seizure medicationsEpileptiform abnormalitiesAcute symptomatic seizuresAcute brain injuryContinuous EEGSecondary prophylaxisSymptomatic seizuresSporadic epileptiform dischargesLateralized periodic dischargesCross-sectional international surveyOutpatient follow-upAnti-seizure medication useOptimal care pathwayDose escalationBrain injuryDose changesLong-term managementElectrographic seizuresEpileptiform dischargesFollow-upAncillary testsReal-world practiceRecommended durationContinuous electroencephalographyHospital discharge
2024
Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures
Zafar S, Sivaraju A, Rubinos C, Ayub N, Awodutire P, McKee Z, Chandan P, Byrnes M, Bhansali S, Rice H, Smith-Ayala A, Haider M, Tveter E, Erlich-Malona N, Ibanhes F, DeMarco A, Lewis S, Dhakar M, Punia V. Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures. JAMA Neurology 2024, 81: 1159-1169. PMID: 39312247, PMCID: PMC11420826, DOI: 10.1001/jamaneurol.2024.3189.Peer-Reviewed Original ResearchAssociated with increased oddsAcute symptomatic seizuresAntiseizure medication treatmentDischarge prescriptionsSymptomatic seizuresAntiseizure medicationsElectrographic seizuresContinuous electroencephalographyOdds of treatmentGlasgow Outcome Scale scoreNeurological intensive care unitOptimal treatment durationMulticenter cohort studyAntiseizure medication useOutcome Scale scorePrescribed antiseizure medicationsAssociated with functional outcomeIntensive care unitAssociated with outcomeMain OutcomesProgressive brain injuryASM treatmentMedication useCohort studyEpileptiform abnormalitiesPredictors of follow-up care for critically-ill patients with seizures and epileptiform abnormalities on EEG monitoring
Rice H, Fernandes M, Punia V, Rubinos C, Sivaraju A, Zafar S. Predictors of follow-up care for critically-ill patients with seizures and epileptiform abnormalities on EEG monitoring. Clinical Neurology And Neurosurgery 2024, 241: 108275. PMID: 38640778, PMCID: PMC11167629, DOI: 10.1016/j.clineuro.2024.108275.Peer-Reviewed Original ResearchConceptsNeurological follow-upFollow-up visitFollow-upAntiseizure medicationsOutpatient follow-upCritically-ill patientsContinuous EEGEpileptiform abnormalitiesPredictors of follow-upPrevent long-term complicationsIllness severityYounger ageRetrospective cohort studyLong-term complicationsFollow-up statusIntensive care unitProbability of follow-upHigher illness severityPredictors of readmissionContinuous EEG recordingsRisk stratificationEEG monitoringCohort studyCritically-illCare unit
2023
Do acute EEG findings add to clinical features in predicting outcomes after status epilepticus and acute symptomatic seizures?
Sivaraju A, Hirsch L. Do acute EEG findings add to clinical features in predicting outcomes after status epilepticus and acute symptomatic seizures? Epilepsy & Behavior 2023, 141: 109134. PMID: 36848748, DOI: 10.1016/j.yebeh.2023.109134.Peer-Reviewed Original ResearchConceptsAcute symptomatic seizuresAnti-seizure medicationsStatus epilepticusEEG findingsSymptomatic seizuresSeizure clinicFunctional outcomeClinical careLong-term clinical careLife-threatening medical emergencyAcute EEG findingsLondon-Innsbruck ColloquiumSubsequent unprovoked seizuresPoor functional outcomeContinuous EEG monitoringAcute seizuresNonconvulsive seizuresClinical featuresPediatric populationUnprovoked seizuresEpileptiform abnormalitiesEpileptic patternsSpecialty clinicTreatment strategiesPrognostic accuracy
2022
Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study
Punia V, Ellison L, Bena J, Chandan P, Sivaraju A, George P, Newey CR, Hantus S. Acute epileptiform abnormalities are the primary predictors of post‐stroke epilepsy: a matched, case–control study. Annals Of Clinical And Translational Neurology 2022, 9: 558-563. PMID: 35243824, PMCID: PMC8994977, DOI: 10.1002/acn3.51534.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyDays of presentationMultivariable logistic modelCase-control studyContinuous EEG monitoringUnivariable analysisStroke patientsEpileptiform abnormalitiesSeizure managementPresence of EAEEG monitoringTherapy trialsEpilepsyPrimary predictorPredictorsLogistic modelPatientsAbnormalitiesTrials