Featured Publications
Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsPrognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome
Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.Peer-Reviewed Original ResearchConceptsBetter outcomesPoor outcomeEpileptiform dischargesPost-cardiac arrest comatose patientsCritical care EEG terminologyPost-cardiac arrest comaMethodsProspective cohort studyContinuous EEG monitoringLow-voltage EEGPositive predictive valueAbsence of reactivityEEG terminologyCohort studySpontaneous circulationBrainstem reflexesClinical outcomesComatose patientsFalse positive ratePoor prognosisPrognostic significanceSuppression burstsClinical variablesClinical correlatesElectroencephalographic patternsElectroencephalographic predictors
2024
Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures
Zafar S, Sivaraju A, Rubinos C, Ayub N, Awodutire P, McKee Z, Chandan P, Byrnes M, Bhansali S, Rice H, Smith-Ayala A, Haider M, Tveter E, Erlich-Malona N, Ibanhes F, DeMarco A, Lewis S, Dhakar M, Punia V. Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures. JAMA Neurology 2024, 81: 1159-1169. PMID: 39312247, PMCID: PMC11420826, DOI: 10.1001/jamaneurol.2024.3189.Peer-Reviewed Original ResearchAssociated with increased oddsAcute symptomatic seizuresAntiseizure medication treatmentDischarge prescriptionsSymptomatic seizuresAntiseizure medicationsElectrographic seizuresContinuous electroencephalographyOdds of treatmentGlasgow Outcome Scale scoreNeurological intensive care unitOptimal treatment durationMulticenter cohort studyAntiseizure medication useOutcome Scale scorePrescribed antiseizure medicationsAssociated with functional outcomeIntensive care unitAssociated with outcomeMain OutcomesProgressive brain injuryASM treatmentMedication useCohort studyEpileptiform abnormalitiesPredictors of follow-up care for critically-ill patients with seizures and epileptiform abnormalities on EEG monitoring
Rice H, Fernandes M, Punia V, Rubinos C, Sivaraju A, Zafar S. Predictors of follow-up care for critically-ill patients with seizures and epileptiform abnormalities on EEG monitoring. Clinical Neurology And Neurosurgery 2024, 241: 108275. PMID: 38640778, PMCID: PMC11167629, DOI: 10.1016/j.clineuro.2024.108275.Peer-Reviewed Original ResearchConceptsNeurological follow-upFollow-up visitFollow-upAntiseizure medicationsOutpatient follow-upCritically-ill patientsContinuous EEGEpileptiform abnormalitiesPredictors of follow-upPrevent long-term complicationsIllness severityYounger ageRetrospective cohort studyLong-term complicationsFollow-up statusIntensive care unitProbability of follow-upHigher illness severityPredictors of readmissionContinuous EEG recordingsRisk stratificationEEG monitoringCohort studyCritically-illCare unitCharacteristics and Attendance of Patients Eligible for the PASS Clinic: A Transition of Care Model After Acute Symptomatic Seizures.
Byrnes M, Thompson N, Hantus S, Fesler J, Ying Z, Ayub N, Rubinos C, Zafar S, Sivaraju A, Punia V. Characteristics and Attendance of Patients Eligible for the PASS Clinic: A Transition of Care Model After Acute Symptomatic Seizures. Neurology Clinical Practice 2024, 14: e200232. PMID: 38213398, PMCID: PMC10781564, DOI: 10.1212/cpj.0000000000200232.Peer-Reviewed Original ResearchAntiseizure medicationsClinic attendanceASY patientsClinic modelCare modelCause-specific Cox proportional hazards modelsMedicare/Medicaid insuranceCox proportional hazards modelAcute symptomatic seizuresClinic attendance ratesClinic visit attendanceEarly postdischarge mortalityProgressive brain injuryRetrospective cohort studyAttendance of patientsRoutine clinical careProportional hazards modelDischarge planning processASM discontinuationAutoimmune encephalitisPostdischarge mortalitySymptomatic seizuresVisit attendanceSeizure clinicCohort study
2023
Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke
Punia V, Li Y, Lapin B, Chandan P, Newey C, Hantus S, Dhakar M, Rubinos C, Zafar S, Sivaraju A, Katzan I, investigators F. Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke. Epilepsy & Behavior 2023, 140: 109115. PMID: 36804847, DOI: 10.1016/j.yebeh.2023.109115.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresAnti-seizure medicationsAcute symptomatic seizuresOutcome measuresSymptomatic seizuresHospital dischargeASM useExact testFirst patient-reported outcome measureRetrospective cohort studyPatient-reported outcomesStandard of careContinuous EEG monitoringFisher's exact testWilcoxon rank sum testChi-square testRank sum testPROM completionStroke clinicCohort studyRecent strokeStroke patientsNeuro-QoLPhysical functionPatients