2021
YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes
Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q, Kontaridis MI, Pu WT, Lin Z. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. International Journal Of Molecular Sciences 2021, 22: 6649. PMID: 34206257, PMCID: PMC8268263, DOI: 10.3390/ijms22136649.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAge FactorsAnimalsCytokinesDNA-Binding ProteinsGene Expression RegulationImmunity, InnateLipopolysaccharidesMiceMice, Inbred C57BLMyocytes, CardiacSignal TransductionTEA Domain Transcription FactorsToll-Like ReceptorsTranscription FactorsYAP-Signaling ProteinsConceptsToll-like receptorsPattern recognition receptorsTLR genesPro-inflammatory cytokinesPathological stressTLR gene expressionToll-like receptor genesInnate immune responseExpression levelsHeart diseaseImmune responseHippo-YAP signalingRecognition receptorsMouse heartsYAP depletionLuciferase reporter dataReceptor geneTerminal effectorAgeReceptorsHomeostasis maintenanceMolecular mechanismsHeartExpressionExpression patterns
2020
Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice
Negron SG, Ercan-Sencicek AG, Freed J, Walters M, Lin Z. Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice. Scientific Reports 2020, 10: 20335. PMID: 33230135, PMCID: PMC7683731, DOI: 10.1038/s41598-020-77362-x.Peer-Reviewed Original ResearchConceptsBrown adipocytesExit cell cycleDevelopmental dynamicsCell cycle activityBrown adipose tissueDifferent growth phasesMolecular mechanismsCell cycleFluorescence-activated cell sorting (FACS) analysisCell sorting (FACS) analysisBAT growthGrowth phaseEssential roleInterscapular BATCycle activityTissue growthDevelopment of BATBrown adipose tissue growthAdipocytesAdipose tissue growthInterscapular brown adipose tissueProliferationGrowthEmbryogenesisLipogenesis