2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2010
Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?
Wisnewski AV, Jones M. Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease? Clinical & Experimental Allergy 2010, 40: 1155-1162. PMID: 20545707, PMCID: PMC3121887, DOI: 10.1111/j.1365-2222.2010.03550.x.Peer-Reviewed Original ResearchConceptsAllergen-specific IgEOccupational asthmaIsocyanate asthmaPro/Con DebateScreening/surveillanceCause of asthmaIgE-mediated diseasesHypersensitive individualsLow molecular weight chemicalsEnvironmental AsthmaAllergic asthmaBronchial hyperreactivityHypersensitivity disordersCommon causeAsthmaPathogenic mechanismsIgEChronic exposureCon debateImportant mediatorDiagnostic testsWeight chemicalsDiseaseHypersensitivityPrevention
2007
Developments in laboratory diagnostics for isocyanate asthma
Wisnewski AV. Developments in laboratory diagnostics for isocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2007, 7: 138-145. PMID: 17351466, PMCID: PMC3131002, DOI: 10.1097/aci.0b013e3280895d22.Peer-Reviewed Original ResearchConceptsIsocyanate asthmaSpecific inhalation challengeCause of asthmaEnzyme-linked immunosorbentBiomarkers of exposureGold standard testInhalation challengeOccupational asthmaAsthma pathogenesisRisk factorsSpecialized centersAsthmaWorkplace exposuresAsthma diagnosticsEfficient laboratory testsHuman IgELaboratory testsClinical diagnosisContemporary laboratory testsLaboratory diagnosticsSubset of workersIgEDisease developmentExposureCause
1999
The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight Asthma
Redlich C, Cain H, Wisnewski A. The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight Asthma. Seminars In Respiratory And Critical Care Medicine 1999, 20: 591-599. DOI: 10.1055/s-2007-1009478.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements