2021
Delayed production of neutralizing antibodies correlates with fatal COVID-19
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, PMCID: PMC8785364, DOI: 10.1038/s41591-021-01355-0.Peer-Reviewed Original ResearchConceptsDeceased patientsAntibody levelsAntibody responseDisease severityAnti-S IgG levelsCOVID-19 disease outcomesFatal COVID-19Impaired viral controlWorse clinical progressionWorse disease severitySevere COVID-19Length of hospitalizationImmunoglobulin G levelsHumoral immune responseCoronavirus disease 2019COVID-19 mortalityCOVID-19Domain (RBD) IgGSeroconversion kineticsDisease courseIgG levelsClinical parametersClinical progressionHumoral responseDisease onset
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Human antibody variable region gene usage in HIV-1 infection.
Wisnewski A, Cavacini L, Posner M. Human antibody variable region gene usage in HIV-1 infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 11: 31-8. PMID: 8528730, DOI: 10.1097/00042560-199601010-00004.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 pathogenesisVariable region gene usageRegion gene usageGene usageHuman immunodeficiency virus type 1 (HIV-1) infectionHIV-1-infected patientsVirus type 1 infectionHuman humoral immune responseAnti-HIV-1 antibodiesDifferent lymphoid compartmentsType 1 infectionHumoral immune responsePeripheral blood lymphocytesPolymerase chain reaction studiesHuman monoclonal antibodyAIDS patientsInfected patientsBlood lymphocytesLymphoid compartmentsGene expressionHIV-1Immune responseSerum IgSerological studies