2024
Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy background
2019
Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study
de Havenon A, Wong K, Elkhetali A, McNally JS, Majersik JJ, Rost NS. Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study. American Journal Of Neuroradiology 2019, 40: 1369-1373. PMID: 31248859, PMCID: PMC7048485, DOI: 10.3174/ajnr.a6115.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensity volumeCarotid artery stiffnessTotal brain volumePressure-strain elastic modulusArtery stiffnessHyperintensity volumeBrain volumeAtherosclerosis RiskArterial stiffnessMR imagingCommunity studyStiffness indexHigher white matter hyperintensity volumeLower total brain volumeSecondary analysisCommon carotid artery stiffnessSmall artery diseaseMultivariable linear regression modelsCerebrovascular diseaseDementia riskSonography measurementsMultivariate modelCarotid strainPotential mechanismsPatients