2023
Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Schilsky M, Ott P, Sandahl T. Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans. Hepatology 2023, 79: 1065-1074. PMID: 38088886, PMCID: PMC11019997, DOI: 10.1097/hep.0000000000000708.Peer-Reviewed Original ResearchUrinary copper excretionStandard uptake valueIntestinal copper absorptionUptake valueCopper excretionIntestinal absorptionPositron emission tomography/CT scanMean standard uptake valueSame therapeutic targetsPET/CT studiesVenous blood samplesCopper absorptionIntestinal copper uptakeEffects of drugsUrinary excretionCT scanHealthy volunteersBlood samplesHealthy humansTrientineTherapeutic targetBody weightCT studiesWilson's diseaseD-penicillamineEffects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Larsen A, Schilsky M, Ott P, Sandahl T. Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease. Journal Of Hepatology 2023, 80: 586-595. PMID: 38081365, DOI: 10.1016/j.jhep.2023.11.023.Peer-Reviewed Original ResearchEffect of tetrathiomolybdateWilson's diseaseBiliary copper excretionBiliary excretionHealthy volunteersCopper excretionWD patientsBis-choline tetrathiomolybdateNeurologic Wilson diseaseClinical trial numberPresent human studyTrial numberPET/CTCopper metabolismIntestinal copper uptakeMechanism of actionPET/MRINeurological worseningConventional therapyVenous bloodClinical trialsLower riskAnimal studiesHuman studiesCopper chelator
2016
Daclatasvir, Sofosbuvir, and Ribavirin Combination for HCV Patients with Advanced Cirrhosis or Post-transplant Recurrence: Final Results of the ALLY-1 Study: 2016 ACG Presidential Poster Award
Poordad F, Schiff E, Vierling J, Landis C, Fontana R, Yang R, McPhee F, Noviello S, Swenson E. Daclatasvir, Sofosbuvir, and Ribavirin Combination for HCV Patients with Advanced Cirrhosis or Post-transplant Recurrence: Final Results of the ALLY-1 Study: 2016 ACG Presidential Poster Award. The American Journal Of Gastroenterology 2016, 111: s346. DOI: 10.14309/00000434-201610001-00774.Peer-Reviewed Original Research
2011
Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors
Swenson ES. Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors. Hepatology 2011, 55: 316-318. PMID: 22190377, DOI: 10.1002/hep.24717.Peer-Reviewed Original Research
2010
Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
Swenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, Volume 3: 1-10. PMID: 21694840, PMCID: PMC3108654, DOI: 10.2147/ceg.s6836.Peer-Reviewed Original ResearchInflammatory bowel diseaseAllogeneic hematopoietic transplantationHost immune responseHematopoietic transplantationMesenchymal stem cellsBlood cell linesBowel diseaseImmune responseGenetic predispositionStem cellsLarge clinical trialsAutologous hematopoietic transplantationAutologous hematopoietic reconstitutionHost diseaseCrohn's diseaseMucosal immunityClinical trialsHematopoietic reconstitutionSmall seriesTransplantationGreater riskCell therapyDiseaseDonor cellsBaseline state
2009
Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells
Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells. Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsHepatocyte growth factorMSC chemotaxisCellular injuryMesenchymal stem cellsAdenosine concentrationRegulation of HGFInhibition of HGFEffects of adenosineSite of injuryBone marrow-derived mesenchymal stem cellsHepatocyte-specific genesHigh adenosine concentrationsHuman marrow-derived mesenchymal stem cellsAdenosine monophosphateBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsConcentration of adenosineLiver injuryCytosolic calcium signalingStress fiber formationA2A receptorsHepatocyte-like cellsCyclic adenosine monophosphate
2008
Chimeric mice reveal clonal development of pancreatic acini, but not islets
Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.Peer-Reviewed Original ResearchConceptsStem/progenitor cellsMultiple progenitorsAdult mouse small intestineMale ES cellsProgenitor cellsFemale blastocystsCrypt stem cellsClonal descendantsES cellsY chromosomeChimeric miceFemale cellsIntestinal crypt stem cellsExocrine pancreatic aciniFemale epithelial cellsClonal developmentStem cellsSitu hybridizationMouse small intestineEpithelial cellsIntestinal cryptsProgenitorsPancreatic aciniCellsPancreatic isletsHepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice
Swenson ES, Guest I, Ilic Z, Mazzeo‐Helgevold M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice. Stem Cells 2008, 26: 1768-1777. PMID: 18467658, PMCID: PMC2846397, DOI: 10.1634/stemcells.2008-0148.Peer-Reviewed Original ResearchConceptsMarrow-derived epithelial cellsHepatocyte nuclear factor 1Y chromosomeNuclear factor 1Ductal progenitor cellsLiver injuryInflammatory cellsFemale miceProgenitor cellsEpithelial cellsFactor 1Male bone marrowStable hematopoietic engraftmentBone marrow originColocalization of GFPNuclear markersBone marrow cellsDuctal progenitorsHematopoietic engraftmentChromosomesBone marrowMarrow originPancytokeratin stainingCholangiocyte phenotypeMarrow cellsPhysiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration
Swenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration. Liver International 2008, 28: 308-318. PMID: 18290773, PMCID: PMC2846401, DOI: 10.1111/j.1478-3231.2007.01659.x.Peer-Reviewed Original ResearchConceptsStromal-derived factor-1Oval cell proliferationLiver injuryLiver irradiationBile ductCell proliferationSDF-1 levelsArterial smooth muscleFactor 1Cell factorMarrow-derived progenitorsNormal mouse liverPlasma levelsBACKGROUND/Murine modelStem cell factorKupffer cellsSmooth muscleInjuryRegenerative responseOval cellsDihydrocollidineMouse liverMiceLiver progenitorsThe hepatic stem cell niche: Identification by label‐retaining cell assay
Kuwahara R, Kofman AV, Landis CS, Swenson ES, Barendswaard E, Theise ND. The hepatic stem cell niche: Identification by label‐retaining cell assay. Hepatology 2008, 47: 1994-2002. PMID: 18454509, PMCID: PMC2847183, DOI: 10.1002/hep.22218.Peer-Reviewed Original ResearchInduced pluripotent cells mimicking human embryonic stem cells.
Mohamadnejad M, Swenson ES. Induced pluripotent cells mimicking human embryonic stem cells. Archives Of Iranian Medicine 2008, 11: 125-8. PMID: 18154436.Peer-Reviewed Original ResearchAdultAgedAnimalsBiomarkersCell DifferentiationCell LineCell ProliferationCell ShapeCells, CulturedCellular ReprogrammingDNA-Binding ProteinsEmbryo, MammalianEmbryonic Stem CellsFemaleFibroblastsGenes, mycHMGB ProteinsHomeodomain ProteinsHumansKaryotypingKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMiceMice, Inbred ICRMice, SCIDMyocytes, CardiacNanog Homeobox ProteinNeuronsOctamer Transcription Factor-3Oligonucleotide Array Sequence AnalysisPluripotent Stem CellsRNA-Binding ProteinsSOXB1 Transcription FactorsStem Cell TransplantationTelomeraseTeratomaTranscription FactorsTransduction, GeneticTransgenes
2007
Limitations of Green Fluorescent Protein as a Cell Lineage Marker
Swenson ES, Price JG, Brazelton T, Krause DS. Limitations of Green Fluorescent Protein as a Cell Lineage Marker. Stem Cells 2007, 25: 2593-2600. PMID: 17615263, DOI: 10.1634/stemcells.2007-0241.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood CellsCattleCell LineageChickensCytomegalovirusFemaleFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGenes, SyntheticGreen Fluorescent ProteinsHumansImmunoenzyme TechniquesMaleMiceMice, Inbred C57BLOrgan SpecificityRegulatory Sequences, Nucleic AcidTissue DistributionTransgenesVisceraConceptsSmall intestineMouse strainsPeripheral blood cellsTransgenic mouse strainReporter mouse strainPrimary rabbit antibodiesDonor originHuman ubiquitin C promoterImmunohistochemical stainingSolid organsCell lineage markersCell lineagesUBC-GFP miceUbiquitin C promoterChicken beta-actinFlow cytometryBlood cellsEnhanced green fluorescent protein (EGFP) reporterMiceOne-tissueAdult liverTissue sectionsIntestineLineage markersRabbit antibodies
Others
- The blood vessels of Prometheus (editorial). ES Swenson and DS Krause. The Hematologist 2011;8:8.Peer-Reviewed Original Research