Samir Zaidi, MD, PhD

Dr. Samir Zaidi, MD, PhD, is an Assistant Professor of Medicine (Medical Oncology) and Stephen Sherwin MD Investigator at the Yale School of Medicine, as well as a member of the Center for Molecular and Cellular Oncology (CMCO) at the Yale Cancer Center. Dr. Zaidi specializes in the treatment of patients with genitourinary cancers.

Dr. Zaidi earned his Bachelor of Science (BS) in Biology from the Massachusetts Institute of Technology (MIT). He then pursued his combined MD and PhD degrees at the Yale School of Medicine and the Graduate School of Arts and Sciences, graduating Cum Laude (MD) and with Distinction (PhD). He completed his internal medicine residency through the Stanbury Physician–Scientist Pathway at Massachusetts General Hospital (MGH) at Harvard Medical School. Following this, Dr. Zaidi joined Memorial Sloan Kettering Cancer Center (MSKCC) for a fellowship in medical oncology, subsequently serving as an Assistant Attending Physician in Genitourinary Oncology and Louis V. Gerstner Physician Scholar.

Returning to Yale from MSKCC, Dr. Zaidi maintains both clinical and research interests in genitourinary cancers, focusing especially on prostate and kidney cancers. His research centers on understanding the tumor-specific and microenvironmental factors contributing to cancer resistance and lineage plasticity. Rooted firmly in basic biology, Dr. Zaidi's scientific approach emphasizes translational research aimed at developing innovative therapeutic strategies. As an integral member of the Yale Cancer Center and CMCO, Dr. Zaidi contributes significantly to initiatives designed to bridge clinical investigation and fundamental cancer biology, ultimately aiming to enhance patient care through improved cancer therapies.