Jay Humphrey, PhD
John C. Malone Professor of Biomedical EngineeringCards
About
Research
Publications
2026
A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli
Shirani M, Humphrey J. A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli. International Journal Of Engineering Science 2026, 223: 104502. DOI: 10.1016/j.ijengsci.2026.104502.Peer-Reviewed Original ResearchMechanisms driving thoracic aortic aneurysm instability
Schwarz E, Li D, Means C, Assi R, Humphrey J. Mechanisms driving thoracic aortic aneurysm instability. Biomechanics And Modeling In Mechanobiology 2026, 25: 43. PMID: 42113285, DOI: 10.1007/s10237-026-02054-w.Peer-Reviewed Original ResearchA systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics
Kim T, Ortigosa R, Nama N, Aguirre M, Gil A, Humphrey J, Figueroa C. A systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics. Journal Of The Mechanical Behavior Of Biomedical Materials 2026, 179: 107423. PMID: 41946235, DOI: 10.1016/j.jmbbm.2026.107423.Peer-Reviewed Original ResearchConceptsVascular biomechanicsRotation-free shell formulationThickness-to-radius ratioIdealized cylindrical geometryComputational costShell formulationMaterial propertiesWall thicknessComparison of membranesComplex geometriesNonlinear membraneBiomechanical applicationsSolid modelQuadratic interpolationCylindrical geometryAxisymmetric solutionsVessel wallWall thickness-to-radius ratioAortic geometryGeometryThicknessFormulationShellWallConvergence analysisProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophagesOptimized biomechanical design of a tissue engineered pulsatile Fontan conduit
Emuna N, Hu Z, Marsden A, Humphrey J. Optimized biomechanical design of a tissue engineered pulsatile Fontan conduit. Npj Regenerative Medicine 2026, 11: 6. PMID: 41540051, PMCID: PMC12859017, DOI: 10.1038/s41536-025-00450-x.Peer-Reviewed Original ResearchA mixed Cosserat and higher gradient formulation for fibrous tissues and biomaterials
Shirani M, Giorgio I, Astori D, Humphrey J. A mixed Cosserat and higher gradient formulation for fibrous tissues and biomaterials. International Journal Of Solids And Structures 2026, 324: 113671. DOI: 10.1016/j.ijsolstr.2025.113671.Peer-Reviewed Original ResearchCosserat effectsFibrous materialsHigher gradient theoriesBalance lawsRank-one convexityEngineering compositesCalculus of variationsPoynting effectGradient elasticityGradient theoryGradient formulationVirtual powerLinear formulationQuasi-convexBoundary conditionsComputational resultsCosseratBiological tissuesNon-classical effects
2025
Predicted Effects of Patient Variability and Notch Signaling on In Situ Vascular Tissue Engineering
van Asten J, Sahlgren C, Humphrey J, Ristori T, Loerakker S. Predicted Effects of Patient Variability and Notch Signaling on In Situ Vascular Tissue Engineering. Annals Of Biomedical Engineering 2025, 54: 393-409. PMID: 41206426, PMCID: PMC12852268, DOI: 10.1007/s10439-025-03843-7.Peer-Reviewed Original ResearchImportance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators
Li D, Goswami S, Cao Q, Oommen V, Assi R, Humphrey J, Karniadakis G. Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators. PLOS Computational Biology 2025, 21: e1013550. PMID: 41066521, PMCID: PMC12520381, DOI: 10.1371/journal.pcbi.1013550.Peer-Reviewed Original ResearchConceptsData formatsNeural network modelInput data formatTraining dataThoracic aortic aneurysmNeural operationsSubject-specific informationNetwork modelPrediction errorArchitectureNetworkAortic aneurysmFull-field measurementsInformationFinite element frameworkRisk of dissectionTrainingPersonalized treatment strategiesElastic fiber integrityUNetThoracic aortopathyCombined insultElement frameworkTreatment strategiesDisease progressionFocal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections
Zhou Z, Guan P, Sarkar R, Yu Y, Richard A, Weiss D, Kawamura Y, Zhang C, Li Y, Vaisar T, Martin D, Buja L, Li Z, Venkatachalam K, Shen Y, LeMaire S, Humphrey J, Milewicz D. Focal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections. JACC Basic To Translational Science 2025, 10: 101353. PMID: 40753710, PMCID: PMC12375202, DOI: 10.1016/j.jacbts.2025.101353.Peer-Reviewed Original ResearchMultiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit.
Hu Z, Herrmann J, Schwarz E, Gerosa F, Emuna N, Humphrey J, Feinberg A, Hsia T, Skylar-Scott M, Marsden A. Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit. Journal Of Biomechanical Engineering 2025, 147 PMID: 40172060, DOI: 10.1115/1.4068319.Peer-Reviewed Original ResearchConceptsSuperior vena cavaInferior vena cavaIncreased cardiac outputCardiac outputVena cavaElevated central venous pressureConduit performanceCongenital heart patientsCentral venous pressureDiminished cardiac outputFluid-structure interactionMultiphysics computational frameworkFontan surgeryFontan circulationFontan physiologyFontan conduitPalliative procedureLumped parameter networkPulmonary arteryCardiomyocyte contractilityValve placementMyocardial contractilityVenous pressureFontanVenous circulation