Hyunghoon (Hoon) Cho, PhD
he/him/his
Cards
About
Research
Publications
2026
Memorization in large language models in medicine prevalence characteristics and implications
Li A, Qian L, Du M, Yin Y, Hu Y, Sun Z, Fu Y, Kim H, Stutz E, Ai X, Xie Q, Zhu R, Huang J, Yang Y, Liu S, Tham Y, Ohno-Machado L, Cho H, Lu Z, Xu H, Chen Q. Memorization in large language models in medicine prevalence characteristics and implications. Nature Communications 2026, 17: 7729. PMID: 42315854, PMCID: PMC13434820, DOI: 10.1038/s41467-026-73779-6.Peer-Reviewed Original ResearchThis study systematically examined what large language models memorize when adapted for medicine, how frequently memorization occurs, how much content is retained, and how it may affect downstream medical applications.Privacy-enhancing sequential learning under heterogeneous selection bias in multi-site electronic health records data
Kundu R, Salvatore M, Patel K, Ohno-Machado L, Cho H, Shi X, Mukherjee B. Privacy-enhancing sequential learning under heterogeneous selection bias in multi-site electronic health records data. Journal Of The American Medical Informatics Association 2026, 33: 1679-1692. PMID: 42298300, PMCID: PMC13580740, DOI: 10.1093/jamia/ocag083.Peer-Reviewed Original Research
2025
Secure phasing of private genomes in a trusted execution environment with TX-Phase
Dokmai N, Zhu K, Sahinalp S, Cho H. Secure phasing of private genomes in a trusted execution environment with TX-Phase. Genome Research 2025, 35: 2626-2636. PMID: 41224532, PMCID: PMC12667372, DOI: 10.1101/gr.280558.125.Peer-Reviewed Original ResearchShechi: A Secure Distributed Computation Compiler Based on Multiparty Homomorphic Encryption.
Smajlović H, Froelicher D, Shajii A, Berger B, Cho H, Numanagić I. Shechi: A Secure Distributed Computation Compiler Based on Multiparty Homomorphic Encryption. 2025, 2025: 7703-7722. PMID: 41685295, PMCID: PMC12892296.Peer-Reviewed Original ResearchGenerating synthetic electronic health record data: a methodological scoping review with benchmarking on phenotype data and open-source software
Chen X, Wu Z, Shi X, Cho H, Mukherjee B. Generating synthetic electronic health record data: a methodological scoping review with benchmarking on phenotype data and open-source software. Journal Of The American Medical Informatics Association 2025, 32: 1227-1240. PMID: 40460023, PMCID: PMC12203555, DOI: 10.1093/jamia/ocaf082.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTX-Phase: Secure Phasing of Private Genomes in a Trusted Execution Environment
Dokmai N, Zhu K, Sahinalp S, Cho H. TX-Phase: Secure Phasing of Private Genomes in a Trusted Execution Environment. Lecture Notes In Computer Science 2025, 15647: 325-329. DOI: 10.1007/978-3-031-90252-9_32.Peer-Reviewed Original ResearchSecure and federated genome-wide association studies for biobank-scale datasets
Cho H, Froelicher D, Chen J, Edupalli M, Pyrgelis A, Troncoso-Pastoriza J, Hubaux J, Berger B. Secure and federated genome-wide association studies for biobank-scale datasets. Nature Genetics 2025, 57: 809-814. PMID: 39994472, PMCID: PMC11985345, DOI: 10.1038/s41588-025-02109-1.Commentaries, Editorials and LettersLearning-augmented sketching offers improved performance for privacy preserving and secure GWAS
Xu J, Zhu K, Cai J, Kockan C, Dokmai N, Cho H, Woodruff D, Sahinalp S. Learning-augmented sketching offers improved performance for privacy preserving and secure GWAS. IScience 2025, 28: 112011. PMID: 40124506, PMCID: PMC11927738, DOI: 10.1016/j.isci.2025.112011.Peer-Reviewed Original Research
2024
Privacy of single-cell gene expression data
Cho H. Privacy of single-cell gene expression data. Patterns 2024, 5: 101096. PMID: 39568471, PMCID: PMC11573887, DOI: 10.1016/j.patter.2024.101096.Peer-Reviewed Original ResearchPrivacy-Enhancing Technologies in Biomedical Data Science
Cho H, Froelicher D, Dokmai N, Nandi A, Sadhuka S, Hong M, Berger B. Privacy-Enhancing Technologies in Biomedical Data Science. Annual Review Of Biomedical Data Science 2024, 7: 317-343. PMID: 39178425, PMCID: PMC11346580, DOI: 10.1146/annurev-biodatasci-120423-120107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Teaching & Mentoring
Mentoring
Haris Smajlović, PhD
Postdoctoral Associate2025 - PresentVincent Angelo
CBB MS Student2025 - PresentDenis Loginov
Senior Software Engineer2024 - PresentLucy Zheng
CBB PhD student2024 - Present
News & Links
News
- May 20, 2026
Cho and Cheng Awarded U01 Grant to Advance Population-Scale Pangenome Research
- April 17, 2026
Two BIDS Trainees Receive 2026 NSF Graduate Research Fellowships
- March 04, 2026
AI in Medicine: Collaborating on Challenges and Opportunities
- October 15, 2025
Program Spotlight: New Human Genome Sciences PhD Track
Get In Touch
Contacts
Email
Academic Office Number
Administrative Support
Locations
101 College Street
Academic Office
Fl 10, Rm 1021M
New Haven, CT 06510