Georges El Fakhri, PhD, DABR
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging, Therapeutic Radiology and of Biomedical Informatics & Data ScienceCards
About
Research
Publications
2025
Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET
Zeng T, Najmaoui Y, Zhang J, Fontaine K, Hu Y, Chemli Y, Gallezot J, Sun C, Lu Y, Fakhri G, Carson R, Marin T. Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287015.Peer-Reviewed Original ResearchSpatially-varying point spread functionPoint spread functionAccurate point spread functionPSF modelConvergence behaviorImage qualityPoint spread function modelReconstruction toolboxPSF parametersHigh-activity regionsBrain-dedicated PET scannersDepth of interactionPoint-spread-function modelingField of viewSpatial resolutionHuman scansContrast recoverySpread functionPET systemPET scannerReal phantomBrain phantomMonte Carlo simulationsBrain positron emission tomographyCarlo simulationsPhysics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET
Chemli Y, Najmaoui Y, Normandin M, Fakhri G, Marin T, Ouyang J. Physics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287851.Peer-Reviewed Original ResearchDeep Image PriorList-modeContrast recoveryMotion correctionList-mode eventsReconstructed activity distributionHoffman brain phantomNoise-resolution trade-offML-EM reconstructionLow-count dataResolution phantomBrain phantomBrain positron emission tomographySuper-resolution effectActivity distributionModel attenuationML-EMBack-projection operationsFine structureDown-sampled dataNegative log-likelihoodImage registrationUnsupervised regularizerBack-projectionImage priorsO119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY.
Depauw N, Bijari F, Garonna A, Kang J, Chemli Y, Deng H, Dhaynaut M, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian M, Fakhri G, Levine R, Lehmann H, Chen Y, Jee K. O119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY. International Journal Of Particle Therapy 2025, 17: 100875. DOI: 10.1016/j.ijpt.2025.100875.Peer-Reviewed Original ResearchMulticenter PET Image Harmonization Using Style-Guided CycleGAN in Primary Central Nervous System Lymphoma : InStyleGAN
Arzur D, Marin T, Horowitz T, Kas A, El Fakhri G, Mhiri I, Rozenblum L. Multicenter PET Image Harmonization Using Style-Guided CycleGAN in Primary Central Nervous System Lymphoma : InStyleGAN. Lecture Notes In Computer Science 2025, 16164: 126-138. DOI: 10.1007/978-3-032-07904-6_12.Peer-Reviewed Original ResearchRobust deep learning modelAdaptive instance normalizationTarget modalityDeep learning modelsInstance NormalizationDistribution alignmentDomain shiftImage harmonizationModel generalizationLatent domainsLearning modelsComputational costNon-scalableCycleGANImage dataData pairsPrimary central nervous system lymphomaAcquisition settingsFrameworkCentral nervous system lymphomaPET dataDomainDataNervous system lymphomaHarmonized frameworkYRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER
Najmaoui Y, Fontaine K, Fontaine D, Zhang J, Zeng T, Volpi T, Chemli Y, Gallezot J, Tétrault M, Carson R, Fakhri G, Marin T. YRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER. 2025, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287275.Peer-Reviewed Original ResearchOpen-sourcePeak-to-valley ratioMini-Derenzo phantomReconstruction platformResolution PET scannerImage reconstruction toolsPacket decodingDetector geometryGPU accelerationMemory usagePET scannerPET systemAccurate system modelMotion correctionScatter estimationVendor softwareReconstruction timeImage reconstructionPluginImage qualitySoftwareHuman datasetsSystem modelManufacturing softwareNon-human primatesLR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization
Djebra Y, Najmaoui Y, Chemli Y, Normandin M, Fakhri G, Ma C, Marin T. LR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization. 2025, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57106.2025.11286709.Peer-Reviewed Original ResearchOn Hallucinations in Artificial Intelligence-Generated Content for Nuclear Medicine Imaging (the DREAM Report).
Xia M, Bayerlein R, Chemli Y, Liu X, Ouyang J, Lin M, El Fakhri G, Badawi R, Li Q, Liu C. On Hallucinations in Artificial Intelligence-Generated Content for Nuclear Medicine Imaging (the DREAM Report). Journal Of Nuclear Medicine 2025, jnumed.125.270653. PMID: 41198241, DOI: 10.2967/jnumed.125.270653.Peer-Reviewed Original ResearchYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchOpen-sourceImage reconstructionPositron emission tomography image reconstructionReconstruction algorithmAdvanced image reconstruction algorithmsOpen-source toolkitDevelopment of advanced algorithmsTime-of-flightScanner geometryNovel reconstruction algorithmImage reconstruction algorithmMotion correctionReusable codeGPU accelerationTime-of-flight informationPython bindingsPlugin systemSoftware toolkitMeaningful imagesData formatsFast implementationRigid motion correctionAdvanced algorithmsPoint spread function modelProprietary softwareAnatomically and metabolically informed diffusion for unified denoising and segmentation in low-count PET imaging
Xia M, Ko K, Wang D, Chen M, Liu Q, Xie H, Guo L, Ji W, Ouyang J, Bayerlein R, Spencer B, Li Q, Badawi R, El Fakhri G, Liu C. Anatomically and metabolically informed diffusion for unified denoising and segmentation in low-count PET imaging. Medical Image Analysis 2025, 107: 103831. PMID: 41076965, PMCID: PMC12551811, DOI: 10.1016/j.media.2025.103831.Peer-Reviewed Original ResearchConceptsPET denoisingDenoising diffusion modelsSuperior performanceImage denoisingDenoised outputMulti-vendorDenoisingInformation diffusionImage informationSegmentation modelAblated versionsDiffusion strategySegmentation methodDice coefficientOrgan segmentationTest casesMulti-task functionRevision moduleTaskImagesAnalysis pipelineSegmentsClinical count levelsTotal lesion glycolysisDatasetDopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation
Borchers L, Dan R, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, El Fakhri G, Normandin M, Pizzagalli D. Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation. Molecular Psychiatry 2025, 1-9. PMID: 40926089, DOI: 10.1038/s41380-025-03218-3.Peer-Reviewed Original ResearchResting-state functional connectivityMajor depressive disorderChildhood sexual abuseDopamine transporter availabilityDepressive disorderPathophysiology of Major Depressive DisorderStriatal dopamine transporter availabilitySexual abuseReward-related regionsSeed-based RSFCVentral tegmental areaDA dysregulationVentral striatumMDD episodeTegmental areaFrontostriatal pathwaysUnmedicated individualsChildhood maltreatmentNeuroimaging investigationsFunctional connectivityTransporter availabilityTreatment targetMRI studiesAbuseCo-occurrence
News
News
- November 10, 2025
NETS Awareness Day 2025
- June 16, 2025
Yale Announces New Biomedical Imaging Institute
- March 05, 2025
PET mapping of receptor occupancy using joint direct parametric reconstruction
- March 03, 2025
Trainee Zhen Li awarded at SPIE Medical Imaging 2025
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