Mechanistic basis for the translation inhibition of Cutibacterium acnes by Clindamycin.
Lomakin I, Devarkar S, Grada A, Bunick C. Mechanistic basis for the translation inhibition of Cutibacterium acnes by Clindamycin. Journal Of Investigative Dermatology 2024 PMID: 39122144, DOI: 10.1016/j.jid.2024.07.013.Peer-Reviewed Original ResearchNetwork of water-mediated interactionsCutibacterium acnesPeptide bond formationNascent peptideWater-mediated interactionsTranslational inhibitionAntibiotic resistanceCryogenic electron microscopyA-resolutionMechanistic basesAntibiotic-based therapiesRRNAAminoacyl groupRibosomeAcne pathogenesisAcne therapyAntibiotic stewardshipClindamycinIncreased resistanceAcne vulgarisClinical targetsAcneAntibioticsPeptideTRNA