A Slow-Go Treatment in Newly Diagnosed AL Amyloidosis with Severe Cardiomyopathy
Hofmeister C, Gupta V, Joseph N, Lonial S, Dhodapkar M, Nooka A, Kaufman J. A Slow-Go Treatment in Newly Diagnosed AL Amyloidosis with Severe Cardiomyopathy. Blood 2024, 144: 4672. DOI: 10.1182/blood-2024-203485.Peer-Reviewed Original ResearchAL amyloidosisPlasma cell-directed therapyHigh-sensitivity troponin THematological complete remissionSevere cardiac involvementCell-directed therapiesPoor performance statusMonths of treatmentEnd-stage cardiomyopathyDaratumumab monotherapyComplete remissionCardiac involvementNT-proBNPPerformance statusAmyloid cardiomyopathyTherapeutic optionsSevere cardiomyopathyHeart transplantationStage 3bDirected therapyDiagnosed patientsEuropean trialsClinical consequencesTroponin TTargeted treatment