Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles.
Frohling S, Scholl C, Levine R, Loriaux M, Boggon T, Bernard O, Berger R, Dohner H, Dohner K, Ebert B, Teckie S, Golub T, Schittenhelm M, Lee B, Griffin J, Stone R, Heinrich M, Deininger M, Druker B, Gilliland D. Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Blood 2007, 110: 206. DOI: 10.1182/blood.v110.11.206.206.Peer-Reviewed Original ResearchAcute myeloid leukemiaHigh-throughput DNA sequence analysisFunctional assessmentActivating mutationsAdult AML patientsGenomic alterationsNovel therapeutic targetReceptor tyrosine kinase FLT3Novel activating mutationsTyrosine kinase FLT3Non-synonymous sequence variantsAML patientsFLT3 inhibitionFLT3 mutationsMyeloid leukemiaTherapeutic targetMalignant transformationAberrant signal transductionJuxtamembrane domainCancer developmentFLT3Mutational profileSingle nucleotide polymorphismsCandidate allelesDNA sequence analysis