2015
Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative
Tarlock K, Hansen M, Hylkema T, Ries R, Farrar J, Auvil J, Gerhard D, Smith M, Davidsen T, Gesuwan P, Hermida L, Marra M, Mungall A, Mungall K, Ma Y, Zong S, Long W, Boggon T, Alonzo T, Kolb E, Gamis A, Meshinchi S. Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative. Blood 2015, 126: 87. DOI: 10.1182/blood.v126.23.87.87.Peer-Reviewed Original ResearchFLT3/ITDChildren's Oncology GroupFLT3 mutationsOncology GroupPediatric cohortPediatric AMLFLT3 geneActivating mutationsTyrosine kinase domainAcute myeloid leukemiaDe novo resistanceInternal tandem duplicationJuxtamembrane domainCommon activating mutationsCo-occurring mutationsTargeted exome captureResistance conferring mutationsCOG trialsChildhood AMLUnnecessary toxicityInhibitor exposureFLT3 inhibitionNovo resistanceAdult studiesExcessive activation
2007
Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles.
Frohling S, Scholl C, Levine R, Loriaux M, Boggon T, Bernard O, Berger R, Dohner H, Dohner K, Ebert B, Teckie S, Golub T, Schittenhelm M, Lee B, Griffin J, Stone R, Heinrich M, Deininger M, Druker B, Gilliland D. Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Blood 2007, 110: 206. DOI: 10.1182/blood.v110.11.206.206.Peer-Reviewed Original ResearchAcute myeloid leukemiaHigh-throughput DNA sequence analysisFunctional assessmentActivating mutationsAdult AML patientsGenomic alterationsNovel therapeutic targetReceptor tyrosine kinase FLT3Novel activating mutationsTyrosine kinase FLT3Non-synonymous sequence variantsAML patientsFLT3 inhibitionFLT3 mutationsMyeloid leukemiaTherapeutic targetMalignant transformationAberrant signal transductionJuxtamembrane domainCancer developmentFLT3Mutational profileSingle nucleotide polymorphismsCandidate allelesDNA sequence analysis