Featured Publications
The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study
Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1371-1383. PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.Peer-Reviewed Original ResearchConceptsSevere respiratory COVID-19COVID-19 severityCOVID-19 outcomesSocio-economic statusMendelian randomization studyObesity-related traitsLower oddsCOVID-19Randomization studyCoronavirus disease 2019 (COVID-19) severityBody mass indexWaist-hip ratioCOVID-19 infectionTwo-sample MR approachAssociation of incomeMultivariable Mendelian randomization study
2022
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
Verma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Petersen JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang R, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung A, O’Donnell C, Gaziano JM, Hauger RL, Iyengar S, Luoh SW, Initiative T. A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1220-1229. PMID: 35771531, PMCID: PMC9746845, DOI: 10.1164/rccm.202109-2166oc.Peer-Reviewed Original ResearchConceptsCOVID-19 hospitalizationIdiopathic pulmonary fibrosisMillion Veteran ProgramHost Genetics InitiativeAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionGene polymorphismsSyndrome coronavirus 2 infectionCoronavirus 2 infectionConfer protective effectsCOVID-19 positivityCoronavirus disease (COVID-19) infectionElectronic health recordsMVP subjectsPneumonia eventsClinical outcomesPulmonary fibrosisCOVID-19 Host Genetics InitiativeClinical eventsSevere outcomesProtective effectSevere diseaseRs35705950Disease severityMVP participantsAssociation of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait
Verma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O’Donnell C, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW, Muralidhar S, Beckham J, Moser J, Thomann L, Garcon H, Kosik N, Damrauer S, Assimes T, Roussos P, Striker R, Tuteja S, DuVall S, Lynch K, Gatsby E, Ramoni R, Breeling J, Huang G, Whitbourne S, Brewer J, Aslan M, Connor T, Argyres D, Stephens B, Brophy M, Humphries D, Selva L, Do N, Shayan S, Churby L, Hauser E, Zhao H, Wilson P, McArdle R, Dellitalia L, Mattocks K, Harley J, Whittle J, Jacono F, Wells J, Gutierrez S, Gibson G, Hammer K, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Mathew R, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Ivins D, Mastorides S, Moorman J, Gappy S, Klein J, Ratcliffe N, Florez H, Okusaga O, Murdoch M, Sriram P, Yeh S, Tandon N, Jhala D, Aguayo S, Cohen D, Sharma S, Liangpunsakul S, Oursler K, Whooley M, Ahuja S, Constans J, Meyer P, Greco J, Rauchman M, Servatius R, Gaddy M, Wallbom A, Morgan T, Stapley T, Sherman S, Ross G, Tsao P, Strollo P, Boyko E, Meyer L, Gupta S, Huq M, Fayad J, Hung A, Lichy J, Hurley R, Robey B. Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait. JAMA Internal Medicine 2022, 182: 796-804. PMID: 35759254, PMCID: PMC9237798, DOI: 10.1001/jamainternmed.2022.2141.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBlack or African AmericanCOVID-19HemoglobinsHumansKidneySickle Cell TraitConceptsAcute kidney failureSickle cell traitAssociation of SCTCOVID-19 outcomesCOVID-19 mortalityKidney diseaseKidney failureCell traitMillion Veteran ProgramCOVID-19Chronic kidney diseaseDiabetic kidney diseaseHypertensive kidney diseaseElectronic health recordsIndex dateAfrican ancestryPulmonary embolismClinical outcomesCerebrovascular diseaseMean ageUnfavorable outcomeClinical dataDiseases codesKidney morbidityMAIN OUTCOMEA Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD, Initiative V, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O’Donnell C, Damrauer SM, Liao KP. A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. PLOS Genetics 2022, 18: e1010113. PMID: 35482673, PMCID: PMC9049369, DOI: 10.1371/journal.pgen.1010113.Peer-Reviewed Original ResearchConceptsSevere COVID-19Million Veteran ProgramPhenome-wide association studyHost Genetics InitiativeGenetic architectureGenotype-phenotype dataAssociation studiesVeterans Affairs Million Veteran ProgramElectronic health record dataCOVID-19 severityHealth record dataCOVID-19Genetic variantsGenetics InitiativeABO locusPhenotypeVenous embolismCritical illnessDiseases codesMedical conditionsInternational ClassificationRecord dataStrong associationVeteran ProgramVariantsAPOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program
Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O’Donnell C, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED, Hung A, Wallbom A, Palacio A, Robey B, Jhala D, Fujii D, Cohen D, Boyko E, Jacono F, Villareal G, Garcon H, Gaziano J, Lichy J, Norton J, Beckham J, Whittle J, Huffman J, Moser J, Greco J, Walsh J, Harley J, Wells J, Klein J, Moorman J, Constans J, Fayad J, Casas J, Xu J, Liao K, Alexander K, Cho K, Hammer K, Oursler K, Mattocks K, Chang K, Dellitalia L, Hamner M, Whooley M, Murdoch M, Gaddy M, Godschalk M, Rauchman M, Huq M, Tandon N, Kosik N, Ratcliffe N, Okusaga O, Roussos P, Strollo P, Meyer P, Sriram P, Wilson P, Liang P, Tsao P, Balasubramanian P, Ramoni R, McArdle R, Hauger R, Servatius R, Smith R, Striker R, Mathew R, Gappy S, Pyarajan S, Gutierrez S, Gupta S, Aguayo S, Sharma S, Damrauer S, Kinlay S, Yeh S, Luoh S, Tuteja S, Mastorides S, Iyengar S, Bhushan S, Muralidhar S, Ahuja S, Liangpunsakul S, Assimes T, Morgan T, Stapley T, Sun Y, Ballas Z. APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. JAMA Internal Medicine 2022, 182: 386-395. PMID: 35089317, PMCID: PMC8980930, DOI: 10.1001/jamainternmed.2021.8538.Peer-Reviewed Original ResearchConceptsAcute kidney injuryNormal kidney functionHigh-risk groupAPOL1 risk variantsKidney functionAKI severityKidney injuryCohort studyMillion Veteran ProgramHigher oddsCOVID-19-associated acute kidney injuryRisk variantsMultivariable logistic regression analysisCOVID-19AKI risk factorsAKI severity stageRetrospective cohort studyAfrican ancestryApolipoprotein L1COVID-19 infectionCoronavirus disease 2019Logistic regression analysisHigh mortality rateVeteran ProgramAPOL1 kidney risk variants
2021
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nature Communications 2021, 12: 4569. PMID: 34315903, PMCID: PMC8316582, DOI: 10.1038/s41467-021-24824-z.Peer-Reviewed Original ResearchConceptsPutative causal genesGenome-wide association studiesUnderstanding of genesIntegrative genomic analysisTrans-ethnic studiesAssociation scanCausal genesGenomic analysisAssociation studiesDiverse ancestral backgroundsGenesSusceptibility genesBiobank JapanHost geneticsProtein levelsAncestral backgroundPathwayExpressionMRNA expressionSplicingRapid progressPhenomeGeneticsHost inflammatory responseCoagulation pathway