Featured Publications
The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study
Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1371-1383. PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.Peer-Reviewed Original ResearchConceptsSevere respiratory COVID-19COVID-19 severityCOVID-19 outcomesSocio-economic statusMendelian randomization studyObesity-related traitsLower oddsCOVID-19Randomization studyCoronavirus disease 2019 (COVID-19) severityBody mass indexWaist-hip ratioCOVID-19 infectionTwo-sample MR approachAssociation of incomeMultivariable Mendelian randomization study
2016
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits
Polimanti R, Yang BZ, Zhao H, Gelernter J. Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. PLOS ONE 2016, 11: e0160654. PMID: 27537407, PMCID: PMC4990182, DOI: 10.1371/journal.pone.0160654.Peer-Reviewed Original ResearchConceptsPolygenic adaptationNatural selectionSystems geneticsProtein interaction networksWide association studyPolygenic mechanismsEuropean populationsPolygenic selectionAnthropometric traitsGene networksHuman genomeEpistatic interactionsInteraction networksEnrichment analysisGenetic signaturesSystems biologyAssociation studiesLipid transportMolecular processesAdaptation signalsLocomotory behaviorTraitsSelective mechanismGeneticsInfection resistance
2015
Genome‐wide association study of body mass index in subjects with alcohol dependence
Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genome‐wide association study of body mass index in subjects with alcohol dependence. Addiction Biology 2015, 22: 535-549. PMID: 26458734, PMCID: PMC5102811, DOI: 10.1111/adb.12317.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAdenylyl CyclasesAdultAlcoholismAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAlpha-Ketoglutarate-Dependent Dioxygenase FTOBlack or African AmericanBody Mass IndexCell Adhesion MoleculesDNA-Binding ProteinsFemaleGenome-Wide Association StudyHSP40 Heat-Shock ProteinsHumansMaleMembrane ProteinsMiddle AgedNerve Tissue ProteinsObesityPolymorphism, Single NucleotideRab GTP-Binding ProteinsRetinal DehydrogenaseRNA, Long NoncodingTranscription FactorsWhite People