CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis
Wannasuphoprasit Y, Andersen SE, Arranz MJ, Catalan R, Jurgens G, Kloosterboer SM, Rasmussen HB, Bhat A, Irizar H, Koller D, Polimanti R, Wang B, Zartaloudi E, Austin-Zimmerman I, Bramon E. CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis. Frontiers In Psychology 2022, 12: 768748. PMID: 35185676, PMCID: PMC8850377, DOI: 10.3389/fpsyg.2021.768748.Peer-Reviewed Original ResearchNormal metabolizersCross-sectional studyPoor metabolizersIntermediate metabolizersSystematic reviewCohort studyWeight gainAntipsychotic treatmentAntipsychotic-Induced Weight GainMost cross-sectional studiesLong-term antipsychoticsCYP2D6 genetic variationCYP2D6 poor metabolizersReduced life expectancyHigher BMIAntipsychotic medicationLiver enzymesClinical dataClinical utilityBMIPsychotic disordersMeta-AnalysisMetabolizersSignificant associationLarger study