2014
Functional variability of glutathione S‐transferases in basque populations
Iorio A, Piacentini S, Polimanti R, De Angelis F, Calderon R, Fuciarelli M. Functional variability of glutathione S‐transferases in basque populations. American Journal Of Human Biology 2014, 26: 361-366. PMID: 24677736, DOI: 10.1002/ajhb.22520.Peer-Reviewed Original ResearchConceptsHuman Genome Diversity ProjectGlutathione S-transferaseS-transferaseFunctional variabilityGenetic structureGenetic association studiesCellular detoxificationGenetic variabilityGenome ProjectGST genesAssociation studiesHigh differentiationDiversity ProjectMediterranean populationsGenesCorrespondence analysisBasque populationEnzyme activityHuman populationDNA extractionPCR multiplexWorldwide populationPCR-RFLP methodPolymorphic variantsDrug response
2013
Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells
De Benedetto ML, Capo CR, Ferri A, Valle C, Polimanti R, Carrì MT, Rossi L. Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. Biochimica Et Biophysica Acta 2013, 1840: 255-261. PMID: 24041990, DOI: 10.1016/j.bbagen.2013.09.008.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBlotting, WesternCation Transport ProteinsCell ProliferationChromatography, AffinityCopperCopper Transporter 1GlutaredoxinsGlutathioneHumansMitochondriaNeuroblastomaOxidation-ReductionReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSuperoxide DismutaseSuperoxide Dismutase-1Tumor Cells, CulturedConceptsIntracellular copper levelsCopper transporter 1Copper-induced toxicityHomeostasis of copperCopper metabolismCopper-binding propertiesGRX1 overexpressionProtein chaperonesHuman neuroblastoma SH-SY5Y cellsCopper overloadCopper chaperoneMajor playersNeuroblastoma SH-SY5Y cellsThioredoxin familyProtein disulfidesGrx1Glutaredoxin-1SH-SY5Y cellsSmall proteinsCuSO4 treatmentNeuronal cellsMixed disulfidesChaperonesControl cellsEnzyme activity