2014
Low-copper diet as a preventive strategy for Alzheimer's disease
Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiology Of Aging 2014, 35: s40-s50. PMID: 24913894, DOI: 10.1016/j.neurobiolaging.2014.02.031.Peer-Reviewed Original ResearchConceptsLow copper dietAlzheimer's diseasePreventive strategiesRisk of ADSporadic Alzheimer's diseaseCopper metabolismAdverse sequelaeDietary intakePathogenetic mechanismsGeneral populationAD riskPathogenic mechanismsDiseaseDietCopper deficiencyRecent studiesRiskMetabolismPhenotypeSequelaeDerangementIntake
2013
Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells
De Benedetto ML, Capo CR, Ferri A, Valle C, Polimanti R, Carrì MT, Rossi L. Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. Biochimica Et Biophysica Acta 2013, 1840: 255-261. PMID: 24041990, DOI: 10.1016/j.bbagen.2013.09.008.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBlotting, WesternCation Transport ProteinsCell ProliferationChromatography, AffinityCopperCopper Transporter 1GlutaredoxinsGlutathioneHumansMitochondriaNeuroblastomaOxidation-ReductionReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSuperoxide DismutaseSuperoxide Dismutase-1Tumor Cells, CulturedConceptsIntracellular copper levelsCopper transporter 1Copper-induced toxicityHomeostasis of copperCopper metabolismCopper-binding propertiesGRX1 overexpressionProtein chaperonesHuman neuroblastoma SH-SY5Y cellsCopper overloadCopper chaperoneMajor playersNeuroblastoma SH-SY5Y cellsThioredoxin familyProtein disulfidesGrx1Glutaredoxin-1SH-SY5Y cellsSmall proteinsCuSO4 treatmentNeuronal cellsMixed disulfidesChaperonesControl cellsEnzyme activityCopper phenotype in Alzheimer's disease: dissecting the pathway.
Squitti R, Polimanti R. Copper phenotype in Alzheimer's disease: dissecting the pathway. American Journal Of Neurodegenerative Disease 2013, 2: 46-56. PMID: 23844331, PMCID: PMC3703119.Peer-Reviewed Original Research