2024
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice
Hasan S, Ghani N, Zhao X, Good J, Huang A, Wrona H, Liu J, Liu C. Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice. Protein & Cell 2024, 15: 661-685. PMID: 38512816, PMCID: PMC11365557, DOI: 10.1093/procel/pwae014.Peer-Reviewed Original ResearchCytosolic phospholipase A2White adipose tissue inflammationAdipose tissue inflammationTissue inflammationState of chronic low-grade inflammationChronic low-grade inflammationHFD-induced weight gainLow-grade inflammationAttenuation of inflammationMolecular targetsPotential therapeutic optionDevelopment of metabolic disordersProtective effect of pyruvateAdipogenic differentiation in vitroDiet-induced obesityNonalcoholic fatty liver diseaseDifferentiation in vitroDrug affinity responsive target stabilityFatty liver diseasePhospholipase A2Meta-inflammationTherapeutic optionsDrug responseGlobal ablationMultifactorial etiology
2021
Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease
Zhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, Liu C. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. Journal Of Molecular Medicine 2021, 99: 1639-1654. PMID: 34453183, PMCID: PMC8541919, DOI: 10.1007/s00109-021-02127-6.Peer-Reviewed Original ResearchConceptsLysosomal storage diseaseGaucher diseaseAutophagosome-lysosome fusionCommon lysosomal storage diseasePGRN deficiencyNovel therapiesAnimal modelsProgranulinLC3-IIMolecular targetsCrucial mediatorCritical moleculesStorage diseaseDiseaseAutophagic fluxC-terminal fragmentImpaired fusionPatient fibroblastsAutophagyImpairmentKey regulator
2013
Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in mice
Zhao Y, Tian Q, Liu C. Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in mice. FEBS Letters 2013, 587: 1805-1810. PMID: 23669357, PMCID: PMC3683372, DOI: 10.1016/j.febslet.2013.04.037.Peer-Reviewed Original ResearchConceptsInflammatory skin diseaseSeverity of dermatitisMouse dermatitis modelNF-κB signalingPotential molecular targetsInflammatory arthritisDermatitis modelSkin inflammationPGRN levelsSevere inflammationProgranulin deficiencySkin diseasesProtective roleInflammationMolecular targetsPGRNAtsttrinDermatitisOxazoloneArthritisTNFαProgranulinDiseaseMiceProtein