2023
Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice
Chen M, Fu W, Xu H, Liu C. Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice. Arthritis Research & Therapy 2023, 25: 146. PMID: 37559125, PMCID: PMC10410869, DOI: 10.1186/s13075-023-03133-4.Peer-Reviewed Original ResearchConceptsInflammatory cell infiltrationPro-inflammatory cytokinesRheumatoid arthritisAnkle jointSerum levelsCell infiltrationMacrophage polarizationOsteoclast activityCartilage damagePathogenesis of RACollagen-induced arthritis modelTau-/- miceCollagen-induced arthritisInflammatory joint diseasePro-inflammatory functionsProgression of CIAPotential therapeutic targetRole of tauInflammatory arthritisBone erosionArthritis incidenceBone lossClinical scoresArthritis modelInflammatory disorders
2018
Targeting tumor necrosis factor receptors in ankylosing spondylitis
Lata M, Hettinghouse A, Liu C. Targeting tumor necrosis factor receptors in ankylosing spondylitis. Annals Of The New York Academy Of Sciences 2018, 1442: 5-16. PMID: 30008173, PMCID: PMC6333510, DOI: 10.1111/nyas.13933.Peer-Reviewed Original ResearchConceptsRole of TNFTumor necrosis factor inhibitorsCourse of ASTargeted biologic therapiesAnti-TNF therapyAutoimmune inflammatory disorderNecrosis factor inhibitorsMore effective treatment strategiesSerious adverse effectsMultiple clinical trialsEffective treatment strategiesPathogenesis of ASTumor necrosis factor receptorNecrosis factor receptorBiologic therapyTNF inhibitorsFactor inhibitorsInflammatory disordersPathogenic roleClinical trialsTreatment strategiesImmune pathwaysTNFTNF biologyTherapy