2023
Suicidal Thoughts and Behaviors in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study
Fischer I, Nichter B, Aunon F, Feldman D, Levy B, Esterlis I, Pietrzak R. Suicidal Thoughts and Behaviors in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2023, 31: 844-852. PMID: 37211498, PMCID: PMC10731861, DOI: 10.1016/j.jagp.2023.04.013.Peer-Reviewed Original ResearchConceptsPast-year suicidal ideationUS military veteransSuicidal ideationLifetime suicide plansSuicide planNational HealthMilitary veteransSuicide intentVeterans StudySuicide attemptsSuicidal thoughtsRepresentative prevalence estimatesMajor depressive disorderLifetime suicide attemptsU.S. military veteransOlder military veteransDepressive disorderPrevalence estimatesLifetime historyProtective factorsSuicide riskPhysical healthLifetime suicideVeteransSelf-report measures
2021
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET
Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET. NeuroImage 2021, 238: 118217. PMID: 34052464, PMCID: PMC8378132, DOI: 10.1016/j.neuroimage.2021.118217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingBrain ChemistryFemaleFluorine RadioisotopesFluorodeoxyglucose F18Gray MatterHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingOrgan SizePositron-Emission TomographyRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5Young AdultConceptsMetabotropic glutamate receptor subtype 5MGluR5 availabilityMultiple brain regionsTissue lossSubtype 5Association cortexPrimary analysisBrain regionsAge-related molecular changesBrain glutamatergic systemBrain tissue lossNon-significant trendPartial volume correctionPositron emission tomographyBrain mGluR5Effect of ageAge-related declineGlutamatergic systemInverse associationTissue alterationsDistribution volumeEmission tomographyOlder ageCognitive functionExploratory analysisIdentifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis
Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D’Souza D, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis. NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.Peer-Reviewed Original ResearchConceptsSynaptic densityResting-state functional magnetic resonance imagingSynaptic vesicle protein 2ALevel-dependent signal fluctuationsBrain networksFunctional magnetic resonance imagingMagnetic resonance imagingAge-related changesHealthy controlsResonance imagingRs-fMRIEffects of sexProtein 2AMultiple comparisonsHuman brainAgePotential utilitySexFirst evidenceCovariance patternsPsychological Resilience to the Challenges of Physical Aging in Older U.S. Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study
Asch RH, Kachadourian L, Southwick SM, Esterlis I, Pietrzak RH. Psychological Resilience to the Challenges of Physical Aging in Older U.S. Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2021, 29: 1280-1285. PMID: 34053836, PMCID: PMC8553809, DOI: 10.1016/j.jagp.2021.04.013.Peer-Reviewed Original ResearchConceptsPsychological resilienceOlder U.S. veteransVeterans StudySecure attachment stylePhysical health difficultiesU.S. veteransU.S. military veteransRelative importance analysisAttachment securityAttachment styleHealth difficultiesNovel analytic approachMilitary veteransIntervention strategiesMindfulnessStrongest correlateGreater resilienceMultiple regressionResilienceVeteransOlder veteransAnalytic approachRepresentative sampleDifficulty indexScores
2020
Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise
Pitts BL, Wen V, Whealin JM, Fogle BM, Southwick SM, Esterlis I, Pietrzak RH. Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise. American Journal Of Geriatric Psychiatry 2020, 28: 959-967. PMID: 32122804, DOI: 10.1016/j.jagp.2020.02.001.Peer-Reviewed Original ResearchConceptsU.S. military veteransVisual learningCognitive functioningMet allele carriersMilitary veteransObjective measuresSubjective cognitive measuresSubjective measuresCognitive dysfunctionEffect of depressionVal66Met genotypeCognitive measuresCognitive AssessmentProcessing speedCognitive functionBDNF Val66Met polymorphismPhysical exerciseVal/ValBDNF Val66Met genotypeFunctioningTreatment effortsModerate decrementsAnalysis of covarianceInteractive effectsLearning