2024
Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults
Griffith F, Ash G, Augustine M, Latimer L, Verne N, Redeker N, O’Malley S, DeMartini K, Fucito L. Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults. Npj Digital Medicine 2024, 7: 342. PMID: 39613828, PMCID: PMC11606959, DOI: 10.1038/s41746-024-01321-3.Peer-Reviewed Original ResearchYoung adultsLanguage processingEvaluating young adultsControl participantsHeavy drinkingSleep factorsImprove sleepNatural language processingPersonalized feedbackParticipation motivationParticipantsSleepAdultsMixed-methods evaluationControl interventionsInterventionConvergent mixed methodsMotivationIncreased awarenessAlcohol
2022
Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation
Waddell JT, Corbin WR, MacKinnon DP, Leeman RF, DeMartini KS, Fucito LM, Kranzler HR, O’Malley S. Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation. Alcohol Clinical And Experimental Research 2022, 46: 477-491. PMID: 35076087, PMCID: PMC9679805, DOI: 10.1111/acer.14780.Peer-Reviewed Original ResearchConceptsMedication dosageYoung adultsLight drinkingSubjective responsesSubjective effectsHeavy drinkingPlacebo-controlled studyEffect sizePerson effectsEffective treatmentNaltrexoneDrinking daysNaltrexone efficacySmall effect sizesDrinking levelsCravingDrinkingAdultsLaboratory-based studiesPillsMomentary assessmentEfficacyTreatment conditionsDrinking environmentsDaily diary data
2020
An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study.
Fucito LM, Wu R, O'Malley SS, Hanrahan TH, Ikomi JT, Muvvala S, Carroll KM, Gueorguieva R. An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study. The Journal Of Smoking Cessation 2020, 15: 119-127. PMID: 33312238, PMCID: PMC7731353, DOI: 10.1017/jsc.2020.13.Peer-Reviewed Original ResearchFeasibility/acceptabilityHeavy drinking smokersAlcohol counsellingHeavy drinkingBehavioral interventionsPilot studyOpen-label vareniclineRandomized pilot studySignificant health burdenComputer-generated tableTobacco pharmacotherapyHealth burdenQuit ratesPilot trialResearch clinicDrinking reductionsVareniclineBehavioural counsellingAlcohol treatmentCombined smokingMedium effect sizeSmokingSmokersCounsellingDrinking
2016
Urgency traits moderate daily relations between affect and drinking to intoxication among young adults
Bold KW, Fucito LM, DeMartini KS, Leeman RF, Kranzler HR, Corbin WR, O’Malley S. Urgency traits moderate daily relations between affect and drinking to intoxication among young adults. Drug And Alcohol Dependence 2016, 170: 59-65. PMID: 27875802, PMCID: PMC5183550, DOI: 10.1016/j.drugalcdep.2016.10.035.Peer-Reviewed Original ResearchConceptsYoung adultsHeavy drinkingEffectiveness of naltrexoneBlood alcohol concentrationHeavy drinking young adultsBrief motivational interventionNaltrexone treatmentClinical trialsHazardous drinkingNaltrexoneSecondary analysisPlaceboTargeted interventionsAge 18Alcohol useIntoxicationLow urgencyAdultsMotivational interventionDrinkingTrait urgencyOddsInterventionCurrent studyRiskDaily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults
Bold KW, Fucito LM, Corbin WR, DeMartini KS, Leeman RF, Kranzler HR, O’Malley S. Daily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults. Experimental And Clinical Psychopharmacology 2016, 24: 367-375. PMID: 27690505, PMCID: PMC5111359, DOI: 10.1037/pha0000090.Peer-Reviewed Original ResearchConceptsYoung adultsDouble-blind clinical trialHeavy drinkingSerious public health problemDose of medicationPublic health problemAlcohol-related interventionsTargeted naltrexoneNaltrexone groupOpioid antagonistRisk factorsClinical trialsFamily historyNaltrexone effectsGreater oddsAlcohol consumptionHealth problemsAlcohol dependenceSecondary analysisPlaceboNaltrexoneNaltrexone's abilityAdultsMedicationsDrinkingNicotine Replacement Therapy Use Predicts Smoking and Drinking Outcomes among Heavy-Drinking Smokers Calling a Tobacco Quitline
Rojewski AM, Fucito LM, Baldassarri S, Hyland A, Cummings KM, Toll BA. Nicotine Replacement Therapy Use Predicts Smoking and Drinking Outcomes among Heavy-Drinking Smokers Calling a Tobacco Quitline. The Journal Of Smoking Cessation 2016, 12: 99-104. PMID: 35082926, PMCID: PMC8788683, DOI: 10.1017/jsc.2016.12.Peer-Reviewed Original ResearchNicotine replacement therapyHeavy drinking daysDrinking daysNRT useFree nicotine replacement therapyNicotine replacement therapy useHeavy drinking smokersState Smokers' QuitlineTobacco counsellingTherapy useCessation assistanceSmoking statusReplacement therapyTobacco quitlineSmoking abstinenceHazardous drinkersSmokersQuitlineHeavy drinkingSuboptimal useDrinking outcomesAbstinenceDaysCounsellingSignificant barriersLongitudinal Findings From a Randomized Clinical Trial of Naltrexone for Young Adult Heavy Drinkers
DeMartini KS, Gueorguieva R, Leeman RF, Corbin WR, Fucito LM, Kranzler HR, O’Malley S. Longitudinal Findings From a Randomized Clinical Trial of Naltrexone for Young Adult Heavy Drinkers. Journal Of Consulting And Clinical Psychology 2016, 84: 185-190. PMID: 26654213, PMCID: PMC4941818, DOI: 10.1037/ccp0000053.Peer-Reviewed Original ResearchConceptsPercent days abstinentFirst placebo-controlled trialPercent days heavy drinkingHeavy drinkingPlacebo-controlled trialLong-term outcomesHeavy drinking daysYoung adults ages 18Adults ages 18Naltrexone conditionActive medicationPlacebo groupPharmacotherapy trialsAdult heavy drinkersYoung adult heavy drinkersNonsignificant decreaseSignificant benefitsYear posttreatmentDays abstinentDrinking daysMost outcomesSingle interventionHeavy drinkersTreatment improvementAge 18
2015
Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE.
Gueorguieva R, Wu R, Fucito LM, O'Malley SS. Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE. Journal Of Studies On Alcohol And Drugs 2015, 76: 935-41. PMID: 26562602, PMCID: PMC4712662, DOI: 10.15288/jsad.2015.76.935.Peer-Reviewed Original ResearchConceptsLong-term outcomesBetter long-term outcomesBetter clinical outcomesDrinking outcomesHeavy drinking daysLogistic regression analysisStrongest predictorLogistic regression modelsPredictors of abstinenceFair classification accuracyPatient characteristicsClinical outcomesTerm outcomesCombined PharmacotherapiesClinical trialsBaseline predictorsTreatment outcomesTreatment phaseOptimizing outcomesDrinking daysBetter outcomesAlcohol Dependence (COMBINE) StudyBehavioral interventionsHeavy drinkingAlternative interventionsAn analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroupsA Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline
Toll BA, Martino S, O’Malley S, Fucito LM, McKee SA, Kahler CW, Rojewski AM, Mahoney MC, Wu R, Celestino P, Seshadri S, Koutsky J, Hyland A, Cummings KM. A Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline. Journal Of Consulting And Clinical Psychology 2015, 83: 445-454. PMID: 25419583, PMCID: PMC5996380, DOI: 10.1037/a0038183.Peer-Reviewed Original ResearchConceptsStandard careHazardous drinkingHigher smoking cessation ratesNew York State Smokers' QuitlineHeavy drinkingBrief motivational counselingSmoking cessation ratesState Smokers' QuitlineBrief alcohol interventionTelephone coachesCessation counselingTreat analysisCessation ratesRandomized trialsTelephone quitlinesCessation successSmoking cessationAcceptable adherenceMotivational counselingQuitlineAlcohol interventionsAlcohol useCareSmokersDrinking
2011
Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers
Peters EN, Leeman RF, Fucito LM, Toll BA, Corbin WR, O'Malley SS. Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers. Addictive Behaviors 2011, 37: 420-426. PMID: 22189052, PMCID: PMC3288288, DOI: 10.1016/j.addbeh.2011.11.036.Peer-Reviewed Original ResearchConceptsCo-occurring marijuana useAdult heavy drinkersYoung adult heavy drinkersHeavy drinkersMedication nonadherenceAlcohol consumptionHigh-risk clinical profileMarijuana useAlcohol-related negative consequencesUse of cigarettesAlcohol-induced disinhibitionBrief individual counselingClinical profileClinical trialsSelf-report assessmentsNonadherenceHeavy drinkingYoung adultsDemographic characteristicsDrinkersIndividual counselingClinical samplesHeavy alcoholMedicationsDrinkingA preliminary investigation of varenicline for heavy drinking smokers
Fucito LM, Toll BA, Wu R, Romano DM, Tek E, O’Malley S. A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology 2011, 215: 655-663. PMID: 21221531, PMCID: PMC3645986, DOI: 10.1007/s00213-010-2160-9.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersActive medicationPretreatment groupAlcohol cravingHeavy drinkersOpen-label phaseSmoking cessation pharmacotherapyEffects of vareniclineHeavy drinking daysGreater reductionPlacebo leadVarenicline pretreatmentCessation counselingCessation pharmacotherapyAbstinence ratesCigarette smokingVareniclineSmoking changesDrinking daysPotential treatmentSmokingAlcohol dependenceEntire study periodSmokersHeavy drinking