Brian Pittman
Statistician 3Cards
About
Research
Publications
2025
Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism.
Naples A, Yang Y, Gravel P, Toyonaga T, Sadabad F, Koohsari S, Pittman B, Gallezot J, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Rodden I, Hillmer A, Esterlis I, Ropchan J, Nabulsi N, Huang Y, Wolf J, Carson R, McPartland J, Matuskey D. Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism. American Journal Of Psychiatry 2025, appiajp20241084. PMID: 41366835, DOI: 10.1176/appi.ajp.20241084.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Glutamate receptor 5Positron emission tomographyAutistic groupGroup differencesPositron emission tomography outcomes measurementsExcitatory neurotransmissionNeurotypical control participantsAutism spectrum disorderReceptor 5Receptor availabilityAutism phenotypeAutistic adultsBrain areasBrain regionsExcitatory neural activitySpectrum disorderControl participantsSensory sensitivityMGlu5Neural activityVenous input functionsReceptor densityAutismEEG power spectraMeasuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study
Sadabad F, Volpi T, Honhar P, Tinaz S, Dias M, Toyonaga T, Naganawa M, Gallezot J, Yang Y, Ibrahim W, Pittman B, Cayir S, Radhakrishnan R, Angarita G, Holmes S, Comley R, Carson R, Finnema S, Matuskey D. Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study. Movement Disorders 2025, 40: 2678-2687. PMID: 41040062, DOI: 10.1002/mds.70041.Peer-Reviewed Original ResearchConceptsC-UCB-JDopamine transporterHealthy controlsVentral striatumDisease stageSubstantia nigraSynaptic densityParkinson's diseaseDopamine transporter availabilityPositron emission tomography imaging studiesSynaptic vesicle glycoprotein 2AAssessment of synaptic densityDopaminergic denervationBetween-group differencesTransporter availabilityBinding potentialNigrostriatal regionDisease durationDual-tracerImaging studiesPatientsPET imagingPresynaptic degenerationPD patientsDopamineBrain white matter microstructure in middle and older aged adults with bipolar disorder: a two-site study
Sankar A, Colic L, Marks R, Rajashekar N, Pittman B, Constable R, Sajatovic M, Eyler L, Blumberg H. Brain white matter microstructure in middle and older aged adults with bipolar disorder: a two-site study. American Journal Of Geriatric Psychiatry 2025 PMID: 41107198, PMCID: PMC12553490, DOI: 10.1016/j.jagp.2025.09.013.Peer-Reviewed Original ResearchBipolar disorderEmotion regulationFractional anisotropyUncinate fasciculusWM microstructureCorpus callosumWM fractional anisotropyBrain white matter microstructureWhite matter microstructureAnterior corpus callosumTwo-site studyPosterior corpus callosumOlder aged adultsMood symptomsConsistent with findingsWhite matterNeurodevelopmental alterationsOlder adulthoodStudy of adults ageWM tractsCognitive impairmentLow FAEffect sizeAge interactionOlder adultsEffects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans
Yang Y, Ibrahim W, Gravel P, Pittman B, Hoye J, Cool R, Sadabad F, Zheng M, Pittenger C, Gallezot J, Carson R, Huang H, Radhakrishnan R, Matuskey D. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans. Molecular Imaging And Biology 2025, 27: 832-838. PMID: 40938339, DOI: 10.1007/s11307-025-02047-8.Peer-Reviewed Original ResearchHigh-resolution research tomographBody mass indexPositron emission tomographyEffects of ageAnterior cingulate cortexPotential confounding effects of ageAge-related declineTwo-tissue compartment modelCingulate cortexReceptor availabilityFrontal cortexParietal cortexOlfactory cortexSubcortical regionsHealthy humansRegional VTCortexConfounding effects of ageCerebellum cortexEmission tomographyTwo-tissueMass indexHealthy individualsInsulaAssessed alterationsBuccal Buprenorphine for Postoperative Analgesia After Thoracic Surgery: Results of a Retrospective Cohort.
Hopkins R, Kudaravalli K, Pittman B, Woodard G, Dhanasopon A, Perrino A, Hickey T. Buccal Buprenorphine for Postoperative Analgesia After Thoracic Surgery: Results of a Retrospective Cohort. Pain Medicine Case Reports 2025, 9: 269-274. PMID: 41031868.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyBuccal buprenorphineAcute pain managementPostoperative pain managementThoracic surgeryPain managementPain outcomesBuccal formulationsMinimally invasive lung surgeryRetrospective cohort study of patientsManagement of acute postoperative painCohort study of patientsAssociated with reduced painOpioid-naive patientsPersistent opioid useMultimodal analgesia strategyAcute postoperative painPerioperative pain managementFormulation of buprenorphineLong-term outcomesStudy of patientsAgonist opioidsPostoperative painAnalgesia strategyRetrospective reviewA prospective assessment of weight bias internalization in patients seeking body contouring after bariatric surgery
Dunford A, Metzler A, Pittman B, Alperovich M, Price G, Ivezaj V. A prospective assessment of weight bias internalization in patients seeking body contouring after bariatric surgery. Surgery For Obesity And Related Diseases 2025, 21: 1350-1356. PMID: 40940272, DOI: 10.1016/j.soard.2025.06.020.Peer-Reviewed Original ResearchEating-disorder psychopathologyWeight bias internalizationDepressive symptomsAssociated with greater eating-disorder psychopathologyAssociated with eating-disorder psychopathologyHigher weight bias internalizationBody contouring surgeryBody mass indexMental health concernsBariatric surgeryPsychopathologyGroup differencesFollow-upSignificant groupBody imageProspective analysisProspective assessmentTime interactionIndependent of body mass indexWeight lossSymptomsUnited States METHODSContouring surgeryParticipantsBariatric teamAntidepressant efficacy of ketamine plus naltrexone for major depression comorbid with alcohol use disorder: a randomized controlled trial
Yoon G, Pittman B, Ralevski E, Petrakis I, Krystal J. Antidepressant efficacy of ketamine plus naltrexone for major depression comorbid with alcohol use disorder: a randomized controlled trial. The International Journal Of Neuropsychopharmacology 2025, 28: pyaf056. PMID: 40795937, PMCID: PMC12395335, DOI: 10.1093/ijnp/pyaf056.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAlcohol use disorderKetamine's therapeutic effectsAntidepressant effectsEfficacy of ketamineAntidepressant efficacyUse disorderGroup differencesComorbidity of major depressive disorderMontgomery-Asberg Depression Rating ScaleTreatment of Major Depressive DisorderAntidepressant efficacy of ketamineComorbid major depressive disorderAntidepressant effects of ketamineNMDA glutamate receptor antagonistDepression Rating ScaleAnti-alcohol effectsAlcohol-related outcomesNo group differencesOpioid receptor antagonismEffects of ketamineKetamine groupAlcohol cravingMADRS changeMontgomery-AsbergBuccal Buprenorphine for Postoperative Analgesia After Major Orthopedic Surgery: Results of a Retrospective Cohort.
Hopkins R, Kudaravalli K, Pittman B, Pour A, Perrino A, Hickey T. Buccal Buprenorphine for Postoperative Analgesia After Major Orthopedic Surgery: Results of a Retrospective Cohort. Pain Medicine Case Reports 2025, 9: 235-241. PMID: 40900458.Peer-Reviewed Original ResearchConceptsBuccal buprenorphineAcute pain managementPain managementPain outcomesAgonist opioidsOrthopedic surgeryBuccal formulationsUS Food and Drug Administration approvalFood and Drug Administration approvalOpioid naive patientsOrthopedic surgery populationMultimodal analgesic regimenChronic pain managementRetrospective chart reviewCohort of patientsPostoperative pain managementFormulation of buprenorphineMajor orthopedic surgeryDrug Administration approvalSuperior safety profileHomogeneous patient populationUsual careOpioid use disorderAnalgesic regimenRetrospective reviewThe Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder.
Costa G, Ra J, Meyerovich J, Pittman B, C Nunes J, De Aquino J. The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder. Journal Of Addiction Medicine 2025 PMID: 40728216, DOI: 10.1097/adm.0000000000001553.Peer-Reviewed Original ResearchOpioid use disorderChildhood Trauma QuestionnaireChildhood traumaSubstance useCannabis initiationUse disorderBrief Pain InventoryEmotional abuseAge of cannabis initiationPain severityChronic painHigher childhood trauma scoresHistory of childhood traumaLikelihood of cannabis useLevels of emotional abuseChildhood trauma exposureChildhood trauma scoresTrauma-focused assessmentAlcohol consumptionHigher alcohol useOpioid use disorder treatment programsTrauma exposureTrauma QuestionnaireCannabis useTrauma subscalesInteractions of alcohol and the benzodiazepine inverse agonist in healthy male volunteers
Singh N, Petrakis I, Pittman B, Luddy C, Krystal J, DSouza D. Interactions of alcohol and the benzodiazepine inverse agonist in healthy male volunteers. Journal Of Psychopharmacology 2025, 39: 715-725. PMID: 40673436, DOI: 10.1177/02698811251330746.Peer-Reviewed Original ResearchConceptsBenzodiazepine partial inverse agonistPartial inverse agonistGABA-A receptorsEthanol intoxicationInverse agonistsGABA-ASedative effectsSedative effects of alcoholAlcohol intoxicationEffects of alcohol intoxicationBenzodiazepine inverse agonistGABA-A receptor subtypesHealthy male volunteersExtrasynaptic GABA-A receptorsWithin-subject designEffects of alcoholStandard alcoholic drinksInteraction of alcoholAffect ScaleAlcohol effectsGABAergic modulationMale volunteersIntravenous alcoholBenzodiazepinesAlcohol drinking
News
News
- July 29, 2025Source: Journal of Addiction Medicine
The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder
- June 26, 2025Source: Alcohol, Clinical and Experimental Research
Pain Interference, Alcohol Use, and Metabolic Health: Insights From a Nationally Representative Study
- February 20, 2025Source: BMJ Mental Health
Chronotherapeutic Intervention Targeting Emotion Regulation Brain Circuitry, Symptoms, and Suicide Risk in Adolescents and Young adults With Bipolar Disorder: A Pilot Randomised Trial
- October 16, 2024Source: Biological Psychiatry
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study