Skip to Main Content

Treatment Studies

Real-time fMRI neurofeedback research trial

HIC: 0206017435

Real-time functional magnetic resonance imaging (fMRI) neurofeedback is a new technique that allows us to train people to control their brain activity patterns. In this research we are investigating whether real-time fMRI neurofeedback can help people control activity in the region of the brain that has been implicated in obsessive-compulsive symptoms-, and whether the neurofeedback reduces these symptoms.

Participation in this study involves multiple visits to the Magnetic Resonance Research Center at the Yale School of Medicine. People will participate in four imaging sessions in which they are asked to try to control their brain patterns. The imaging sessions are non-invasive but do involve exposure to symptom provoking images. The full study takes approximately a month to complete.

This is a registered clinical trial ( identifier: NCT02206945) and is funded by the National Institute of Mental Health (R01 MH100068).

Trigriluzole augmentation for the treatment of refractory OCD

Several lines of evidence suggest that the neurotransmitter glutamate is overactive in at least some cases of OCD. Medications that modulate glutamate in the brain may therefore represent a new avenue to treat OCD symptoms, and may be of use in patients whose symptoms do not respond well to standard methods of treatment. Some years ago, the Yale OCD Research Clinic began investigating the glutamate-modulating drug riluzole (Rilutek®), which is FDA-approved for the treatment of the neurological disease amyotrophic lateral sclerosis. In early research, without a control group, we found riluzole to be helpful to some people with severe, treatment-refractory OCD, and that this benefit can persist for over a year after initial treatment. In a follow-up placebo-controlled study, funded by the National Institute of Mental Health, and published in 2015, we again found evidence for benefit in some people, though the study was not large enough to constitute definitive proof. 

Our current research, performed together with the pharmaceutical company Biohaven, and with collaborating sites across the country, aims to test the efficacy of a similar new medicine, trigriluzole, in people with OCD. Trigriluzole has been designed to be more convenient and easier to use than riluzole, with fewer side effects. Once in the body, it is transformed into riluzole, and thus we expect it to have similar benefits. Through this placebo-controlled study, we hope to better understand whether or not glutamate-modulating medications have a role in the treatment of OCD after first-line medication has been tried, and to take an important step towards making a new glutamate-targeting treatment available to people.

This is a registered clinical trial ( identifier: NCT03299166).

Neural correlates of the effects of psilocybin in OCD

HIC: 2000020355     Principal Investigator: Benjamin Kelmendi, MD 

Previous research has suggested that psilocybin may reduce OCD symptoms, but this has never been tested in a controlled study. We are investigating whether a single dose of psilocybin can lead to improvement in OCD symptoms and/or brain changes in comparison with a placebo control. Participants will receive either psilocybin or placebo. Several preparatory sessions prior to drug administration will ensure comfort and safety. These sessions will also provide a psychological framework to guide participants’ experience. The drug will be administered in a comfortable setting with two clinical facilitators. Psychological and medical monitoring will be provided. If given placebo, participants will be invited to receive psilocybin at a later date. After receiving psilocybin, there will be multiple follow-up evaluations over a span of 12 weeks. 

This is a registered clinical trial ( identifier: NCT03356483).