Publications

Compartmentalized nutrient and hormone sensing in β-cells: the role of cilia

Hughes J, Merrins M. Compartmentalized nutrient and hormone sensing in β-cells: the role of cilia. Physiology 2025 PMID: 41432705, DOI: 10.1152/physiol.00042.2025.

Peer-Reviewed Original Research

Endothelial Rho kinase controls blood vessel integrity and angiogenesis

Lange M, Francis C, Furtado J, Granger J, Kim Y, Liao J, Akar F, Eichmann A. Endothelial Rho kinase controls blood vessel integrity and angiogenesis. Cardiovascular Research 2025, cvaf246. PMID: 41403023, DOI: 10.1093/cvr/cvaf246.

Peer-Reviewed Original Research

Characterization of arteriovenous thrombus formation and propagation in a mouse arteriovenous fistula model

bai H, Li Z, Ho B, Cai Y, Hwa J, Dardik A. Characterization of arteriovenous thrombus formation and propagation in a mouse arteriovenous fistula model. Thrombosis And Haemostasis 2025 PMID: 41401940, DOI: 10.1055/a-2772-5837.

Peer-Reviewed Original Research

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition

Leitner B, Fosam A, Lee W, Zilinger K, Nakandakari S, Zhang X, Gaspar R, Zhu W, Perry C, Rabinowitz J, Perry R. Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2508707122. PMID: 41325517, PMCID: PMC12704748, DOI: 10.1073/pnas.2508707122.

Peer-Reviewed Original Research

GARLH regulates neuroligin preference for excitatory versus inhibitory synapses

Yamasaki T, Konno K, Krueger-Burg D, Noam Y, Chaudhury N, Morimoto-Tomita M, Salm E, Watanabe M, Brose N, Tomita S. GARLH regulates neuroligin preference for excitatory versus inhibitory synapses. Journal Of Cell Biology 2025, 225: e202507190. PMID: 41329163, DOI: 10.1083/jcb.202507190.

Peer-Reviewed Original Research

Resolving the mysteries of brain clearance and immune surveillance

Kipnis J, Benveniste H, Eichmann A, Thomas J, Reich D, Lewis L, Tsai L, Drieu A, Bakker E, Kelley D, Lundgaard I, Mestre H, Zott B, Eide P, van Osch M, van Veluw S, Iliff J, Yang A, Santambrogio L, Da Mesquita S, Daneman R, Rustenhoven J, Goldman S, Nedergaard M. Resolving the mysteries of brain clearance and immune surveillance. Neuron 2025, 113: 3908-3923. PMID: 41289996, DOI: 10.1016/j.neuron.2025.10.036.

Peer-Reviewed Original Research

ARMH2 is a cytosolic component of CatSper crucial for sperm function

De Rito C, Sassi G, Percudani R, Chung J. ARMH2 is a cytosolic component of CatSper crucial for sperm function. Nature Communications 2025, 16: 10243. PMID: 41271765, PMCID: PMC12638846, DOI: 10.1038/s41467-025-65952-0.

Peer-Reviewed Original Research

Hypothalamic Prostaglandins Facilitate Recovery From Severe Hypoglycemia but Exacerbate Recurrent Hypoglycemia in Mice.

Abe T, Xu S, Sugiura Y, Arima Y, Hayasaka T, Lee M, Ishimoto T, Araki Y, Ngurari S, Niu Z, Iijima N, Diano S, Toda C. Hypothalamic Prostaglandins Facilitate Recovery From Severe Hypoglycemia but Exacerbate Recurrent Hypoglycemia in Mice. Diabetes 2025, 74: 2390-2404. PMID: 41264848, DOI: 10.2337/db25-0106.

Peer-Reviewed Original Research

Turbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia

Varsanik M, Thaxton C, Nguyen D, Pugar J, Dhara S, Li W, Nguyen N, Dardik A, Pocivavsek L. Turbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia. Physics In Medicine And Biology 2025, 70: 235009. PMID: 41183446, DOI: 10.1088/1361-6560/ae1ac8.

Peer-Reviewed Original Research

The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice.

Srivastava S*, Kato H*, von Kroge S*, Weise K, Stabach P, Lopez SG, O'Brien K, Lester ER, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema KJ, Carpenter TO, Sabbagh Y, Tommasini SM, Ito N, Oheim R, Braddock DT. The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. Journal of Bone and Mineral Research. 2025 PMID: 41251406, DOI: 10.1093/jbmr/zjaf168.

Peer-Reviewed Original Research

The prevalence of ENPP1 deficiency in humans with Ossification of the Posterior Longitudinal Ligament and the preclinical efficacy of ENPP1 enzyme therapy in murine Ossification of the Posterior Longitudinal Ligament

Srivastava S, Kato H, von Kroge S, Weise K, Stabach P, Lopez S, O’Brien K, Lester E, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema K, Carpenter T, Sabbagh Y, Tommasini S, Ito N, Oheim R, Braddock D. The prevalence of ENPP1 deficiency in humans with Ossification of the Posterior Longitudinal Ligament and the preclinical efficacy of ENPP1 enzyme therapy in murine Ossification of the Posterior Longitudinal Ligament. Journal Of Bone And Mineral Research 2025, zjaf168. PMID: 41251406, DOI: 10.1093/jbmr/zjaf168.

Peer-Reviewed Original Research

Pathophysiology of Atherosclerotic Carotid Disease

Ho B, Batarseh P, Dardik A. Pathophysiology of Atherosclerotic Carotid Disease. Seminars In Neurology 2025 PMID: 41248882, DOI: 10.1055/a-2735-9854.

Peer-Reviewed Original Research

Interactions among tumor subtype, PPARγ expression, and adipose proliferation shape outcomes in breast cancer

Shah A, Liu K, Liu R, Ramshankar G, Perry C, Perry R. Interactions among tumor subtype, PPARγ expression, and adipose proliferation shape outcomes in breast cancer. Physiological Reports 2025, 13: e70649. PMID: 41236441, PMCID: PMC12617248, DOI: 10.14814/phy2.70649.

Peer-Reviewed Original Research

How might intraluminal drug-delivery strategies be improved to enhance arteriovenous fistula maturation and patency?

George J, Rao A, Dardik A. How might intraluminal drug-delivery strategies be improved to enhance arteriovenous fistula maturation and patency? Expert Opinion On Drug Delivery 2025, ahead-of-print: 1-4. PMID: 41208053, DOI: 10.1080/17425247.2025.2588377.

Peer-Reviewed Original Research

Concepts

Gut Microbiota and Dietary Strategies for Age-Related Diseases

Prabhat Upadhyay*, Sudhir Kumar*, Hanish Singh Jayasingh Chellammal, Neha Sahu, Shivani Srivastava, Raj Kumar, and Amin Gasmi. Gut Microbiota and Dietary Strategies for Age-Related Diseases. Molecular Nutrition & Food Research. 2025; e70308. PMID: 41195914, DOI: 10.1002/mnfr.70308

Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

Gut Microbiota and Dietary Strategies for Age‐Related Diseases

Upadhyay P, Kumar S, Chellammal H, Sahu N, Srivastava S, Kumar R, Gasmi A. Gut Microbiota and Dietary Strategies for Age‐Related Diseases. Molecular Nutrition & Food Research 2025, 69: e70308. PMID: 41195914, DOI: 10.1002/mnfr.70308.

Peer-Reviewed Original Research

Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression

Furtado J, Zapadka T, Park H, Boyé K, Demb J, Eichmann A. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression. Cellular And Molecular Life Sciences 2025, 82: 389. PMID: 41196411, PMCID: PMC12592616, DOI: 10.1007/s00018-025-05903-6.

Peer-Reviewed Original Research

Chronic pulmonary LPS exposure in cystic fibrosis drives maladaptive pro-inflammatory hematopoietic stem and progenitor cells

Isler Mancuso R, Thompson E, Braga C, Oez H, Gudneppanavar R, Zhang P, Neves T, Krause W, Huang P, Murray T, Egan M, Bruscia E, Krause D. Chronic pulmonary LPS exposure in cystic fibrosis drives maladaptive pro-inflammatory hematopoietic stem and progenitor cells. Blood 2025, 146: 3175-3175. DOI: 10.1182/blood-2025-3175.

Peer-Reviewed Original Research

Polyunsaturated fatty acids control lipid membrane dynamics and ferroptosis sensitivity in B-cell lymphoma

Leveille E, Bramson E, Robinson M, Perez C, Chahal O, Bertomeu T, Chatr-aryamontri A, Kothari S, Gupta K, Karatekin E, Xiao G, Lancaster G, Murphy A, Conrad M, Müschen M. Polyunsaturated fatty acids control lipid membrane dynamics and ferroptosis sensitivity in B-cell lymphoma. Blood 2025, 146: 5094-5094. DOI: 10.1182/blood-2025-5094.

Peer-Reviewed Original Research

Altered Epithelial-Mesenchymal Progenitor States Lead to Matrix Deposition, Tissue Inflammation, and Transitional Epithelial State in Congenital Diaphragmatic Hernia

Rivero R, Edelstein S, Haynes C, Mizoguchi S, Wang N, Saltzman M, Stitelman D, Raredon M. Altered Epithelial-Mesenchymal Progenitor States Lead to Matrix Deposition, Tissue Inflammation, and Transitional Epithelial State in Congenital Diaphragmatic Hernia. Fetal And Pediatric Pathology 2025, 44: 551-572. PMID: 41246903, DOI: 10.1080/15513815.2025.2585371.

Peer-Reviewed Original Research

The role of the ventromedial hypothalamus in glycemic responses

Zilinger K, Perry R. The role of the ventromedial hypothalamus in glycemic responses. Cell Metabolism 2025, 37: 2097-2098. PMID: 41192357, DOI: 10.1016/j.cmet.2025.10.004.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

Optimal treatment of preclinical cardiovascular disease: a narrative review with a focus on carotid artery stenosis

Paraskevas K, Mikhailidis D, Myrcha P, AbuRahma A, Blecha M, Mansilha A, Blinc A, Heiss C, Sawicka A, Setacci C, Zeebregts C, Spinelli F, Stilo F, Witte M, Lanza G, Jug B, Hendiger W, Myrcha J, Taranta I, Goryn T, D’Oria M, Fernandes e Fernandes J, Reijnen M, di Lazzaro V, Lepidi S, Goudot G, Lal B, Jawien A, Lavie C, Mackevicius A, Baltrunas T, Głowiński J, Liapis C, Menyhei G, Secemsky E, Stanek A, Saba L, Balestrieri A, Ferreira J, Lanza J, Crupi D, Pitha J, Pecoraro F, Setacci F, Svetlikov A, Gurevich V, Silvestrini M, Pilato F, Schneider P, White C, Reiff T, Gargiulo M, Faggioli G, Chaturvedi S, Malas M, Perler B, Dardik A, Nicolaides A, Poredos P, Hicks C. Optimal treatment of preclinical cardiovascular disease: a narrative review with a focus on carotid artery stenosis. Seminars In Vascular Surgery 2025 DOI: 10.1053/j.semvascsurg.2025.11.003.

Peer-Reviewed Original Research

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

Elliott S, Ready P, Wrinn C, Ma Q, Edward M, Niescier R, Escobar I, Sun J, Ganga A, McAtee C, Atiş İ, Koleske A, Bordey A, Breslow D. A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. Science Advances 2025, 11: eaeb7238. PMID: 41160700, PMCID: PMC12571082, DOI: 10.1126/sciadv.aeb7238.

Peer-Reviewed Original Research

Glucose restriction regulates osteoblasts function by modulating mitochondrial activity and lipolysis

Menale C, Sozio C, La Rosa G, Trinchese G, Yoon N, Palmiero A, Aiello I, Raia M, Scalia G, Dentice M, Mollica M, Diano S. Glucose restriction regulates osteoblasts function by modulating mitochondrial activity and lipolysis. The Journal Of Nutritional Biochemistry 2025, 148: 110158. PMID: 41167494, DOI: 10.1016/j.jnutbio.2025.110158.

Peer-Reviewed Original Research

Cellular and synaptic mechanisms of retinal processing

Demb J, Dedek K, Li W. Cellular and synaptic mechanisms of retinal processing. The Journal Of Physiology 2025, 603: 6469-6471. PMID: 41139330, DOI: 10.1113/jp290088.

Peer-Reviewed Original Research