Publications

2025

• The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice.

  Srivastava S*, Kato H*, von Kroge S*, Weise K, Stabach P, Lopez SG, O'Brien K, Lester ER, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema KJ, Carpenter TO, Sabbagh Y, Tommasini SM, Ito N, Oheim R, Braddock DT. The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. Journal of Bone and Mineral Research. 2025 PMID: 41251406, DOI: 10.1093/jbmr/zjaf168.

  Peer-Reviewed Original Research

• The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice

  Srivastava S, Kato H, von Kroge S, Weise K, Stabach P, Lopez S, O’Brien K, Lester E, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema K, Carpenter T, Sabbagh Y, Tommasini S, Ito N, Oheim R, Braddock D. The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. Journal Of Bone And Mineral Research 2025, zjaf168. PMID: 41251406, DOI: 10.1093/jbmr/zjaf168.

  Peer-Reviewed Original Research

  Concepts

• Gut Microbiota and Dietary Strategies for Age-Related Diseases

  Prabhat Upadhyay*, Sudhir Kumar*, Hanish Singh Jayasingh Chellammal, Neha Sahu, Shivani Srivastava, Raj Kumar, and Amin Gasmi. Gut Microbiota and Dietary Strategies for Age-Related Diseases. Molecular Nutrition & Food Research. 2025; e70308. PMID: 41195914, DOI: 10.1002/mnfr.70308

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

• Gut Microbiota and Dietary Strategies for Age‐Related Diseases

  Upadhyay P, Kumar S, Chellammal H, Sahu N, Srivastava S, Kumar R, Gasmi A. Gut Microbiota and Dietary Strategies for Age‐Related Diseases. Molecular Nutrition & Food Research 2025, e70308. PMID: 41195914, DOI: 10.1002/mnfr.70308.

  Peer-Reviewed Original Research

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• A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

  . A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. Science Advances 2025, 11: eaeb7238. PMID: 41160700, PMCID: PMC12571082, DOI: 10.1126/sciadv.aeb7238.

  Peer-Reviewed Original Research

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• Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy

  Schwartz A, Carter W, Tonnessen B, Arhuidese I, Cardella J, Dardik A, Ochoa Chaar C. Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy. Journal Of Vascular Surgery 2025 PMID: 40992521, DOI: 10.1016/j.jvs.2025.09.032.

  Peer-Reviewed Original Research

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• Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration

  Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.

  Peer-Reviewed Original Research

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• Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system

  Tan K, Hillgen-Santa L, Graham M, Li Y, Liu X, Pang S, Gracheva E, Bagriantsev S. Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system. Current Biology 2025 PMID: 40945511, PMCID: PMC12478595, DOI: 10.1016/j.cub.2025.08.035.

  Peer-Reviewed Original Research

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• Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.

  Rao V, Cox Z, Ivey-Miranda J, Moreno-Villagomez J, Ramos-Mastache D, Maulion C, Bellumkonda L, Turner J, Wilson F, Shilpak M, Estrella M, Welling P, Wilcox C, Ellison D, Forbush B, Testani J. Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial. Journal Of The American Society Of Nephrology 2025 PMID: 40938670, DOI: 10.1681/asn.0000000887.

  Peer-Reviewed Original Research

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• Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models

  Castelo Branco Ramos Nakandakari S, Elliott E, Fudoli Lins Vieira R, da Silva Rios T, Fosam A, Betim Pavan I, Maftoum Costa M, Salvino da Silva L, de Oliveira Ramos C, Rios Gonçalves G, Akingbesote N, Sidarta-Oliveira D, Moreli A, Rosseto Braga R, Pinto A, Eisenstein A, Velloso L, Simabuco F, Pauli J, Rochete Ropelle E, Ramos da Silva A, Wang A, Perry R, Cintra D. Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models. AJP Endocrinology And Metabolism 2025, 329: e663-e675. PMID: 40938960, DOI: 10.1152/ajpendo.00147.2025.

  Peer-Reviewed Original Research

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• BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

  Hanna M, Rodriguez Cruz H, Fujise K, Wu Y, Xu C, Pang S, Li Z, Monetti M, De Camilli P. BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM. The EMBO Journal 2025, 1-28. PMID: 40935891, DOI: 10.1038/s44318-025-00543-9.

  Peer-Reviewed Original Research

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• Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism

  Liu R, Zhang Z, Kyaw A, Grabińska K, Shah H, Shen H. Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism. Nature Metabolism 2025, 7: 1871-1888. PMID: 40925986, PMCID: PMC12460162, DOI: 10.1038/s42255-025-01358-y.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway

  Zheng J, Gaspar R, Sakuma I, Hubbard B, Zhang D, Nasiri A, Kahn M, Perelis M, Samuel V, Petersen K, Shulman G. Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway. Diabetologia 2025, 1-15. PMID: 40908405, DOI: 10.1007/s00125-025-06539-8.

  Peer-Reviewed Original Research

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• Smoking Cessation After Carotid Revascularization in the Vascular Quality Initiative

  Schwartz A, Carter W, Zwibelman H, Lemmon G, Cardella J, Dardik A, Guzman R, Chaar C. Smoking Cessation After Carotid Revascularization in the Vascular Quality Initiative. Journal Of Vascular Surgery 2025, 82: e46-e47. DOI: 10.1016/j.jvs.2025.05.199.

  Peer-Reviewed Original Research

• Using SPIDRs to map the RNA-protein web

  Thoreen C. Using SPIDRs to map the RNA-protein web. Molecular Cell 2025, 85: 3355-3356. PMID: 40972524, DOI: 10.1016/j.molcel.2025.08.033.

  Peer-Reviewed Original Research

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• Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell

  Bai J, Zhang C, Bahader I, Strenzke N, Renigunta V, Oliver D, Navaratnam D, Beckstein O, Santos-Sacchi J. Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell. Structure 2025 PMID: 40865532, DOI: 10.1016/j.str.2025.08.016.

  Peer-Reviewed Original Research

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• Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

  Onysk A, Steczkiewicz K, Radkiewicz M, Link‐Lenczowski P, Surowiecki P, Sztompka K, Grabińska K, Nowak J, Surmacz L. Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia. The FEBS Journal 2025 PMID: 40847593, DOI: 10.1111/febs.70237.

  Peer-Reviewed Original Research

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• Frailty and Functional Decline after Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians

  Li J, Slade M, Gill T, Bader J, Guzman R, Tonnessen B, Kuwayama D, Dardik A, Cardella J, Ochoa Chaar C. Frailty and Functional Decline after Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians. Journal Of Vascular Surgery 2025 PMID: 40835162, DOI: 10.1016/j.jvs.2025.08.011.

  Peer-Reviewed Original Research

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• Calpain in Traumatic Brain Injury: From Cinderella to Central Player

  Schallerer C, Neuschmid S, Ehrlich B, McGuone D. Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Cells 2025, 14: 1253. PMID: 40862734, PMCID: PMC12384584, DOI: 10.3390/cells14161253.

  Peer-Reviewed Original Research

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• A comprehensive model of blood flow restriction in the postsurgical rat

  Fosam A, Nakandakari S, Miranda I, Taber C, O'Connell J, Raines A, Ohashi Y, Bai H, Dardik A, Allen C, Perry R. A comprehensive model of blood flow restriction in the postsurgical rat. Physiological Reports 2025, 13: e70495. PMCID: PMC12325096, DOI: 10.14814/phy2.70495.

  Peer-Reviewed Original Research

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• A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection

  Pell J, Tanvir E, Sun Z, Reghuvaran A, Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188.

  Peer-Reviewed Original Research

• Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation

  Aoyagi Y, Schwartz A, Li Z, Bai H, Ho B, Lazcano-Etchebarne C, Gonzalez L, Ohashi Y, Kano M, Yatsula B, Chaar C, Martin K, Vazquez-Padron R, Dai G, Dardik A. Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation. JVS Vascular Science 2025, 100392. DOI: 10.1016/j.jvssci.2025.100392.

  Peer-Reviewed Original Research

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• Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat

  Rivera-Gonzalez G, Butka E, Gonzalez C, Mintz R, Kleb S, Josephson V, Kong W, Jindal K, Kamimoto K, Shook B, Rodeheffer M, Morris S. Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat. Cell Stem Cell 2025, 32: 1267-1284.e8. PMID: 40744015, PMCID: PMC12338953, DOI: 10.1016/j.stem.2025.07.004.

  Peer-Reviewed Original Research

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• TMBIM4 affects left-right patterning via pluripotency exit during gastrulation

  Diab N, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha M. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Developmental Biology 2025, 527: 136-146. PMID: 40744297, DOI: 10.1016/j.ydbio.2025.07.018.

  Peer-Reviewed Original Research

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• Contribution of individual excitatory synapses on dendritic spines to electrical signaling

  Weng J, Ceballos C, Zecevic D. Contribution of individual excitatory synapses on dendritic spines to electrical signaling. Frontiers In Neuroscience 2025, 19: 1620654. PMID: 40799917, PMCID: PMC12339456, DOI: 10.3389/fnins.2025.1620654.

  Peer-Reviewed Original Research

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