2024
Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiency
2023
3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original ResearchGround squirrels – experts in thermoregulatory adaptation
Feketa V, Bagriantsev S, Gracheva E. Ground squirrels – experts in thermoregulatory adaptation. Trends In Neurosciences 2023, 46: 505-507. PMID: 37188617, DOI: 10.1016/j.tins.2023.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
CNGA3 acts as a cold sensor in hypothalamic neurons
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. ELife 2020, 9: e55370. PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/elife.55370.Peer-Reviewed Original Research
2019
A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors
2015
Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents
Feketa V, Marrelli S. Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents. PLOS ONE 2015, 10: e0141994. PMID: 26528923, PMCID: PMC4631363, DOI: 10.1371/journal.pone.0141994.Peer-Reviewed Original ResearchConceptsHypothermic effectConscious patientsNovel pharmacological methodHigh intravenous dosesInduction of hypothermiaTherapeutic hypothermiaBlood pressureIntravenous dosesSuboptimal effectivenessConscious rodentsPromising new strategySystemic administrationIntravenous administrationCold-seeking behaviorPharmacological methodsSubstantial toxicityHypothermia inductionSafe dosesHypothermiaChannel activationPatientsCore temperatureMiceAdministrationDoses
2014
Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse
Feketa V, Zhang Y, Cao Z, Balasubramanian A, Flores C, Player M, Marrelli S. Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse. Critical Care Medicine 2014, 42: e355-e363. PMID: 24595220, PMCID: PMC4137592, DOI: 10.1097/ccm.0000000000000229.Peer-Reviewed Original ResearchConceptsTRP melastatin 8TRP vanilloid 1Transient receptor potential channelsConscious miceTRPM8 inhibitorTransient receptor potential vanilloid 1 (TRPV1) activationCore temperatureAged male miceProspective animal studyAcademic medical centerPotential channelsCerebral ischemiaLoading doseDose-dependent dropMechanical ventilationVanilloid 1TRPV1 agonistsCardiac arrestCold defense responsesContinuous infusionAged miceHypothermic effectTherapeutic rangeMale miceHypothermic response
2013
Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition
Feketa V, Balasubramanian A, Flores C, Player M, Marrelli S. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. AJP Regulatory Integrative And Comparative Physiology 2013, 305: r1040-r1050. PMID: 24005250, PMCID: PMC3840321, DOI: 10.1152/ajpregu.00296.2013.Peer-Reviewed Original ResearchConceptsTachycardic responsesTRPV1 activationMuscle activityCore temperatureTRPM8 inhibitionConscious stroke patientsRole of TRPM8TRPM8 KO miceTreatment of strokeElectromyographic muscle activityInduction of hypothermiaCold-induced shiveringTherapeutic hypothermiaStroke patientsConscious miceTRPV1 agonistsKO miceAbdominal cavityTachycardiaBack musclesEffective hypothermiaMild decreaseProfound dropShiveringHypothermia