2018
Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition
Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ. Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition. Neuron 2018, 97: 368-377.e3. PMID: 29346754, PMCID: PMC5777295, DOI: 10.1016/j.neuron.2017.12.032.Peer-Reviewed Original ResearchConceptsDendritic inhibitionInput-specific long-term potentiationNMDA-type glutamate receptorsGABAergic inhibitory synapsesSomatostatin-expressing interneuronsGABA-A receptorsNormal brain functionLong-term potentiationForms of plasticityHomeostatic cellular mechanismsGABAergic inhibitionSynaptic excitationPerisomatic inhibitionPostsynaptic spikingInhibitory synapsesLong-term plasticityGlutamate receptorsInhibitory inputsSynaptic transmissionDependent potentiationCortical circuitsGenetic deletionBrain functionNeuronal dendritesCellular mechanisms
2016
CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S. CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron 2016, 92: 75-83. PMID: 27667007, PMCID: PMC5059846, DOI: 10.1016/j.neuron.2016.09.002.Peer-Reviewed Original ResearchConceptsCaMKII phosphorylation siteCaMKII substratePhosphorylation sitesDependent protein kinase IIProtein kinase IIReceptor-dependent activationNMDA receptor-dependent activationProtein phosphorylationAMPAR-mediated transmissionKinase IICaMKII-dependent enhancementLong-term potentiationCaMKII phosphorylationCellular mechanismsPhosphorylationMolecular targetsAMPA receptorsCrucial mediatorSynaptic plasticityMemory formationSynaptic insertionEssential stepSynaptic transmissionActivity-dependent strengtheningBasal transmission