Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
Martinac B, Bavi N, Ridone P, Nikolaev YA, Martinac AD, Nakayama Y, Rohde PR, Bavi O. Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile. Biophysical Reviews 2018, 10: 1377-1384. PMID: 30182202, PMCID: PMC6233343, DOI: 10.1007/s12551-018-0450-3.Peer-Reviewed Original ResearchTransbilayer pressure profileMS channelsIon channel mechanosensitivityLipid bilayersMechanosensitive ion channelsSubmillisecond time scaleMembrane lipid environmentStructure-function relationshipsChannel mechanosensitivityMembrane proteinsDownstream effectorsLipid environmentIntracellular signalsCellular membranesConformational changesBiophysical principlesChannel reconstitutionIon channelsMechanical stimuliTime scalesPressure profileSpecific interactionsMechanical forcesCentral roleReconstitution method