Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule
Wang T. Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. American Journal Of Physiology 1997, 272: f242-f248. PMID: 9124402, DOI: 10.1152/ajprenal.1997.272.2.f242.Peer-Reviewed Original ResearchConceptsKidney proximal tubulesS-nitroso-N-acetylpenicillamineSodium nitroprussideProximal tubulesL-NAMEGuanylate cyclase inhibitor methyleneN(G)-nitro-L-arginine methyl esterBlood pressureNitric oxideNa+ transportStimulatory effect of sodium nitroprussideN(G)-nitro-L-arginineNitric oxide synthase inhibitorCGMP-mediated mechanismAddition of L-NAMEIncreased urine flow rateGlomerular filtration rateEffects of sodium nitroprussideMean blood pressureUrine flow rateEffects of nitric oxideRenal excretion of NaExcretion of NaRenal hemodynamicsEffects of NO