2016
Abstract P189: Disruption of Cyp2c44 Increases Sodium Chloride Cotransporter Expression and Activity in the Distal Convoluted Tubule
Su X, Wang L, Gao Z, Lin D, Pandey V, Wang T, Abraham N, Schwartzman M, Wang W. Abstract P189: Disruption of Cyp2c44 Increases Sodium Chloride Cotransporter Expression and Activity in the Distal Convoluted Tubule. Hypertension 2016, 68 DOI: 10.1161/hyp.68.suppl_1.p189.Peer-Reviewed Original ResearchNaCl cotransporterNCC expressionEpoxyeicosatrienoic acidsENaC activityRegulation of renal sodium transportFat diet-induced increaseIncreased ENaC activityAlanine-rich kinaseEffect of hydrochlorothiazideRenal sodium transportDietary Na intakeDistal convoluted tubuleCytochrome-P450Cotransporter expressionWT miceRenal expressionNCC activityKO miceNa intakeNa excretionCyp2c44Sodium transportNa transportNa absorptionENaC
2006
Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC
Sun P, Lin D, Wang T, Babilonia E, Wang Z, Jin Y, Kemp R, Nasjletti A, Wang W. Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. American Journal Of Physiology. Renal Physiology 2006, 291: f1192-f1200. PMID: 16849695, DOI: 10.1152/ajprenal.00112.2006.Peer-Reviewed Original ResearchMeSH Keywords8,11,14-Eicosatrienoic AcidAnimalsArachidonic AcidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEpithelial Sodium ChannelsFemaleIon Channel GatingKidney Tubules, CollectingMaleMembrane PotentialsPatch-Clamp TechniquesRatsRats, Sprague-DawleySodium, DietarySpecific Pathogen-Free OrganismsConceptsExpression of CYP2C23Low Na intakeCollecting ductsMS-PPOHEpoxyeicosatrienoic acidsDistal nephronArachidonic acidNa intakeInhibition of CYP epoxygenaseNa transportNa absorptionArachidonic acid-induced inhibitionControl Na dietInhibition of ENaC.Na-deficient dietNormal-Na dietActivation of ENaCEpithelial Na channelPatch-clamp studiesHigh-Na dietIncreased Na absorptionAA-induced inhibitionInhibitory effectENaC activityNa restriction