1985
Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1983
Specificity and modes of the anion exchanger in dog renal microvillus membranes
Guggino SE, Martin GJ, Aronson PS. Specificity and modes of the anion exchanger in dog renal microvillus membranes. American Journal Of Physiology 1983, 244: f612-f621. PMID: 6859253, DOI: 10.1152/ajprenal.1983.244.6.f612.Peer-Reviewed Original Research