2009
Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat
Zerwekh JE, Zou L, Pak CY, Moe OW, Preisig PA. Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat. Bone 2009, 45: 1004-1009. PMID: 19651255, PMCID: PMC2753741, DOI: 10.1016/j.bone.2009.07.077.Peer-Reviewed Original ResearchConceptsHigh animal protein intakeAnimal protein intakeAlkali therapyBone histomorphometryBone turnoverProtein intakeAcid loadChronic acid loadMajor skeletal effectCancellous bone volumeHigh casein dietNegative calcium balanceDynamic bone histomorphometryLow urinary pHBone formation rateDietary animal protein intakeStatic bone histomorphometryNet acid excretionLow caseinSubstantial acid loadOsteoclastic surfaceWesternized dietUrinary pHUrine biochemistryBone resorption
2003
Effect of high protein diet on stone-forming propensity and bone loss in rats
Amanzadeh J, Gitomer WL, Zerwekh JE, Preisig PA, Moe OW, Pak CY, Levi M. Effect of high protein diet on stone-forming propensity and bone loss in rats. Kidney International 2003, 64: 2142-2149. PMID: 14633136, DOI: 10.1046/j.1523-1755.2003.00309.x.Peer-Reviewed Original ResearchConceptsHigh casein dietHigh casein groupBone lossCasein groupCasein dietHigh-protein dietProtein dietPathogenesis of hypercalciuriaSerum calcitriol concentrationsStone-forming propensityUrinary calcium excretionBrush border membraneRisk of nephrolithiasisUrinary citrate excretionHigh protein intakeLow casein dietHigher urinary volumeResponse of kidneyNet acid excretionSubstantial acid loadKidney stone formationDays of studyCalcium excretionCalcitriol concentrationsCortical brush border membrane
1999
Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth?
Al-Awqati Q, Preisig P. Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth? Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10551-10553. PMID: 10485857, PMCID: PMC33735, DOI: 10.1073/pnas.96.19.10551.Peer-Reviewed Original Research