2021
C. elegans discriminates colors to guide foraging
Ghosh DD, Lee D, Jin X, Horvitz HR, Nitabach MN. C. elegans discriminates colors to guide foraging. Science 2021, 371: 1059-1063. PMID: 33674494, PMCID: PMC8554940, DOI: 10.1126/science.abd3010.Peer-Reviewed Original ResearchConceptsCellular stress response genesCellular stress response pathwaysStress response genesStress response pathwaysPhotoreceptor genesDiverse phylaC. elegansForaging decisionsResponse pathwaysResponse genesForagingOpsinGenesPhotosensitive cellsNatural environmentCaenorhabditisHarmful bacteriaElegansPhylaOrganismsBacteriaPathwayRoundwormsCellsToxinDopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila
McCurdy LY, Sareen P, Davoudian PA, Nitabach MN. Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila. Nature Communications 2021, 12: 1115. PMID: 33602917, PMCID: PMC7893153, DOI: 10.1038/s41467-021-21388-w.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsCholinergic neuronsNeural circuit mechanismsCholinergic relayDopaminergic mechanismsSynaptic excitationSynaptic reconstructionSynaptic inputsVivo functional imagingCircuit mechanismsNeuronsAversive memoryFunctional imagingOdor responsesAversive outcomesReduced activationSuch activationCircuit motifsActivationOutcomesElectric shock punishmentSensory cuesUnexpected omissionShock punishmentBehavioral analysis
2016
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2014
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila
Aso Y, Sitaraman D, Ichinose T, Kaun KR, Vogt K, Belliart-Guérin G, Plaçais PY, Robie AA, Yamagata N, Schnaitmann C, Rowell WJ, Johnston RM, Ngo TT, Chen N, Korff W, Nitabach MN, Heberlein U, Preat T, Branson KM, Tanimoto H, Rubin GM. Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. ELife 2014, 3: e04580. PMID: 25535794, PMCID: PMC4273436, DOI: 10.7554/elife.04580.Peer-Reviewed Original Research