2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCircadian ClocksDrosophila melanogasterDrosophila ProteinsLocomotionMaleNeuropeptidesReceptors, Cell SurfaceConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCord
2013
Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits
Choi C, Nitabach MN. Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits. Physiology 2013, 28: 164-171. PMID: 23636262, PMCID: PMC4073904, DOI: 10.1152/physiol.00056.2012.Peer-Reviewed Original ResearchConceptsMembrane-tethered ligandsCellular circuitsCell surface receptorsCognate cell surface receptorsCell-autonomous mannerG protein-coupled receptorsCell-specific promoterIon channel subtypesIntercellular communication pathwaysRecombinant transgeneBiological processesStructural modulesBiological circuitsBiological significanceIon channelsSpecific phenotypesSurface receptorsCommunication pathwaysPhysiological circuitsSpecific manipulationChannel subtypesReceptorsSuch manipulationsPharmacological manipulationPromoter