2021
Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila
McCurdy LY, Sareen P, Davoudian PA, Nitabach MN. Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila. Nature Communications 2021, 12: 1115. PMID: 33602917, PMCID: PMC7893153, DOI: 10.1038/s41467-021-21388-w.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsCholinergic neuronsNeural circuit mechanismsCholinergic relayDopaminergic mechanismsSynaptic excitationSynaptic reconstructionSynaptic inputsVivo functional imagingCircuit mechanismsNeuronsAversive memoryFunctional imagingOdor responsesAversive outcomesReduced activationSuch activationCircuit motifsActivationOutcomesElectric shock punishmentSensory cuesUnexpected omissionShock punishmentBehavioral analysis
2011
Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons
McCarthy EV, Wu Y, deCarvalho T, Brandt C, Cao G, Nitabach MN. Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons. Journal Of Neuroscience 2011, 31: 8181-8193. PMID: 21632940, PMCID: PMC3125135, DOI: 10.1523/jneurosci.2017-10.2011.Peer-Reviewed Original ResearchConceptsSynaptic inputsWhole-cell patch-clamp recordingsNicotinic acetylcholine receptor antagonistDual whole-cell patch-clamp recordingsAcetylcholine receptor antagonistNicotinic ACh receptorsSynchronous synaptic inputPatch-clamp recordingsWake-promoting neuronsLarge ventrolateral neuronsArousal neuronsSodium blockersGABAergic inputsCholinergic inputReceptor antagonistSynaptic circuitryACh receptorsNeurotransmitter receptorsBilateral inputSynaptic connectionsΑ-bungarotoxinVentrolateral neuronsContralateral pairsFiring patternsNeurons