2022
An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster
Gkanias E, McCurdy LY, Nitabach MN, Webb B. An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster. ELife 2022, 11: e75611. PMID: 35363138, PMCID: PMC8975552, DOI: 10.7554/elife.75611.Peer-Reviewed Original ResearchConceptsFlexible behavioral controlConditioning paradigmNeural mechanismsNegative reinforcementMemory acquisitionBehavioral controlMemory dynamicsExploration/exploitationDrosophila melanogasterPlasticity rulesMushroom bodiesComputational modellingAcquisitionMemorySpecific neuronsStimuliDifferent rolesParadigmDrosophilaMelanogasterInsectsShort termFindingsNeuronsDopaminergic
2017
Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila
Chen D, Sitaraman D, Chen N, Jin X, Han C, Chen J, Sun M, Baker BS, Nitabach MN, Pan Y. Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila. Nature Communications 2017, 8: 154. PMID: 28754889, PMCID: PMC5533705, DOI: 10.1038/s41467-017-00087-5.Peer-Reviewed Original Research
2014
Rhythmic control of activity and sleep by class B1 GPCRs
Kunst M, Tso MC, Ghosh DD, Herzog ED, Nitabach MN. Rhythmic control of activity and sleep by class B1 GPCRs. Critical Reviews In Biochemistry And Molecular Biology 2014, 50: 18-30. PMID: 25410535, PMCID: PMC4648372, DOI: 10.3109/10409238.2014.985815.Peer-Reviewed Original ResearchConceptsGenetic model organismClass B1 GPCRsModel organismsC. elegansMetazoan cladesMolecular roleCircadian timekeepingB1 familyMolecular mechanismsG proteinsRhythmic controlDaily rhythmsCircadian rhythmRemarkable parallelsMultiple cellsDrosophilaCladeElegansPDFRGPCRsIntercellularReceptorsOrganismsVPAC2 receptorsTimekeeping
2013
Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila
Krupp JJ, Billeter JC, Wong A, Choi C, Nitabach MN, Levine JD. Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila. Neuron 2013, 79: 54-68. PMID: 23849197, PMCID: PMC3955580, DOI: 10.1016/j.neuron.2013.05.019.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorClock cellsMating behaviorPheromone productionNeuropeptide Pigment Dispersing FactorPeripheral clock cellsMale sex pheromoneSex pheromone productionMolecular rhythmsPhysiological outputsNeuropeptide signalingBehavioral rhythmsCircadian mechanismsSex-specific differencesDrosophilaSex pheromoneCircadian entrainmentOenocytesCircadian systemPheromonePathwayNeuroendocrine pathwaysActivity rhythmsCellsBehavioral processesA biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells
Cabrero P, Richmond L, Nitabach M, Davies SA, Dow JA. A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells. Proceedings Of The Royal Society B 2013, 280: 20122943. PMID: 23446525, PMCID: PMC3619477, DOI: 10.1098/rspb.2012.2943.Peer-Reviewed Original ResearchMeSH KeywordsAequorinAnimalsApoproteinsCalcium SignalingChloridesDrosophila melanogasterDrosophila ProteinsGreen Fluorescent ProteinsInositol 1,4,5-Trisphosphate ReceptorsMalpighian TubulesModels, BiologicalNeuropeptidesPhospholipase C betaProtein EngineeringRecombinant ProteinsTyramineWater-Electrolyte BalanceConceptsTrisphosphate receptor geneCalcium signalsStellate cellsTranslational fusionInsect osmoregulationDistinct tissuesIntracellular calciumMode of actionPhospholipase CIntracellular calcium signalsReceptor geneIndependent mechanismsHalf-maximal activationTyramine-induced increaseUAS controlITPRTyramine actEndocrine controlRenal functionCellsNeuropeptides actPrincipal cellsKininsDrosophilaNorpA