2009
Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*
Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ. Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*. Journal Of Biological Chemistry 2009, 284: 21011-21026. PMID: 19491093, PMCID: PMC2742866, DOI: 10.1074/jbc.m109.017756.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAmino AcidsAnimalsCalciumCell NucleusChlorocebus aethiopsCOS CellsExtracellular SpaceGenes, ReporterHumansIntracellular SpaceMiceMutant ProteinsProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalProtein TransportStructure-Activity RelationshipTRPP Cation Channels
1998
Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase.
Blostein R, Daly SE, Boxenbaum N, Lane LK, Arguello JM, Lingrel JB, Karlish SJ, Caplan MJ, Dunbar L. Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase. Acta Physiologica Scandinavica. Supplementum 1998, 643: 275-81. PMID: 9789570.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionCytoplasmIsoenzymesMutationProtein ConformationSodium-Potassium-Exchanging ATPaseConceptsM2-M3 loopCytoplasmic domainCytoplasmic loopK-ATPaseN-terminusStructure/function analysisTransmembrane segment M2Amino-terminal halfMajor cytoplasmic loopFifth transmembrane segmentFirst cytoplasmic loopCatalytic phosphorylation siteMajor conformational statesLow catalytic turnoverPutative cationCytoplasmic mutantsTransmembrane segmentsPhosphorylation sitesTransmembrane domainAlpha 1 subunitSegment M2Cytoplasmic regionApparent affinityAmino terminusTerminal half