2000
The C-terminal Tail of the Metabotropic Glutamate Receptor Subtype 7 Is Necessary but Not Sufficient for Cell Surface Delivery and Polarized Targeting in Neurons and Epithelia*
McCarthy J, Lim S, Elkind N, Trimmer J, Duvoisin R, Rodriguez-Boulan E, Caplan M. The C-terminal Tail of the Metabotropic Glutamate Receptor Subtype 7 Is Necessary but Not Sufficient for Cell Surface Delivery and Polarized Targeting in Neurons and Epithelia*. Journal Of Biological Chemistry 2000, 276: 9133-9140. PMID: 11106656, DOI: 10.1074/jbc.m008290200.Peer-Reviewed Original ResearchConceptsPolarized targetingCytoplasmic tailIntracellular compartmentsMadin-Darby canine kidney epithelial cellsVesicular stomatitis virus G proteinComplex neuronal functionMDCK cellsCell surface deliveryC-terminal tailCanine kidney epithelial cellsCytoplasmic tail domainVirus G proteinKidney epithelial cellsEntire cell surfaceCell surface expressionCytoplasmic domainTransmembrane portionSurface deliveryTail domainSynaptic microdomainsHuman placental alkaline phosphataseNeuronal polarizationMolecular signalsG proteinsCultured hippocampal neurons
1995
Developmental regulation of membrane protein sorting in Drosophila embryos
Shiel MJ, Caplan MJ. Developmental regulation of membrane protein sorting in Drosophila embryos. American Journal Of Physiology 1995, 269: c207-c216. PMID: 7631747, DOI: 10.1152/ajpcell.1995.269.1.c207.Peer-Reviewed Original ResearchConceptsDrosophila embryosMembrane proteinsSurface ectodermTransgenic Drosophila embryosVesicular stomatitis virus G proteinDrosophila melanogaster embryosMammalian epithelial cellsPlacental alkaline phosphataseApical plasma membraneVirus G proteinBasolateral proteinsSorting pathwaysCytosolic portionDevelopmental regulationHuman placental alkaline phosphatasePlasma membraneBasolateral distributionChimeric constructsSubcellular distributionG proteinsApical membraneInternal epitheliumEmbryosProteinApical surface