Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development 2011, 138: 4709-4719. PMID: 21989915, PMCID: PMC3190384, DOI: 10.1242/dev.067710.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdipogenesisAdipose Tissue, WhiteAnimalsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicroarray AnalysisNF-E2-Related Factor 2Promoter Regions, GeneticProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2ConceptsTranscription factorsWhite adipose tissue developmentGene networksAdipose tissue developmentGene expressionTissue developmentETS transcription factorsEarly gene clusterDistinct transcriptional programsWAT developmentAdipocyte differentiation programImportant transcription factorFormation of adipocytesMotif discovery toolsGene clusterEarly adipogenesisTranscriptional programsDifferentiation programBAC transgenic miceDNA microarraysDevelopmental transitionsMolecular mechanismsMolecular characterizationSignificant enrichmentEts2