Mai Oda
Associate Research ScientistCards
About
Research
Publications
2025
The inner core enables transient touch detection in the Pacinian corpuscle
Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.Peer-Reviewed Original Research
2023
Human TRPV1 structure and inhibition by the analgesic SB-366791
Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.Peer-Reviewed Original ResearchConceptsSB-366791Transient receptor potential (TRP) ion channelsPotential ion channelsPain pathwaysPain therapyPain treatmentPsychiatric disordersOpioid crisisTherapy targetTRPV1 inhibitorElectrophysiological recordingsHuman TRPV1TRP channelsTRPV1New drugsDisease conditionsVanilloid subfamilyIon channelsTreatmentInhibitorsOpioidsPainTherapyDiseaseCryo-electron microscopy structure
2021
Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation
Oda M, Fujiwara Y, Ishizaki Y, Shibasaki K. Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation. Biochemistry And Biophysics Reports 2021, 28: 101173. PMID: 34841092, PMCID: PMC8605382, DOI: 10.1016/j.bbrep.2021.101173.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 2Response to 2-APBTransient receptor potential vanilloid 2 activationOocyte expression systemTwo-electrode voltage clamp recordingsMechanical stimulationVoltage clamp recordingsChemical ligandsOxidant chloramine TNoxious heatClamp recordingsOxidation of methionine residuesHeat stimuliTRP channelsTwo-electrodeOxidationLigandExpression systemStimulationChloramine TOocytesCell expression systemMethionine residuesMammalian cell expression systemChemicalChoroidal congestion mouse model: Could it serve as a pachychoroid model?
Matsumoto H, Mukai R, Hoshino J, Oda M, Matsuzaki T, Ishizaki Y, Shibasaki K, Akiyama H. Choroidal congestion mouse model: Could it serve as a pachychoroid model? PLOS ONE 2021, 16: e0246115. PMID: 33507997, PMCID: PMC7843010, DOI: 10.1371/journal.pone.0246115.Peer-Reviewed Original ResearchConceptsPachychoroid spectrum diseasesRetinal pigment epitheliumVortex vein congestionVortex veinsSpectrum diseaseChoroidal vesselsUltra-widefield indocyanine green angiographyDilated outer choroidal vesselsDilation of choroidal vesselsMouse modelRPE flatmountsVein congestionDilated vortex veinsOuter choroidal vesselsIndocyanine green angiographyInflammatory response-related genesWild type miceOptical coherence tomographyTissue sectionsDay 7 groupChoroidal congestionChoroidal thickeningPachychoroid featuresRPE degenerationMacular disorders
2019
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells
Oda M, Yamamoto H, Matsumoto H, Ishizaki Y, Shibasaki K. TRPC5 regulates axonal outgrowth in developing retinal ganglion cells. Laboratory Investigation 2019, 100: 297-310. PMID: 31844148, DOI: 10.1038/s41374-019-0347-1.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cell layerRetinal ganglion cell axon outgrowthTRPC5 expressionDepletion of intracellular calcium storesAmacrine cellsExcessive Ca<sup>2+</sup> entryDeath of retinal ganglion cellsExpression of TRPC5Ganglion cellsAxonal outgrowthIntracellular calcium storesMuller glial cellsNitric oxideMature retinal ganglion cellsRetinal cell typesIn situ hybridizationCentral nervous systemTRPC5 activityCalcium storesTRPC5Characteristic cell morphologyMouse retinaGlial cellsHippocampal neurons
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